Desoxycortone pivalate
Also known as: Zycortal
This medication is a long-term replacement therapy for your pet's missing hormones. **Do not miss doses.** Regular blood tests will be required to check electrolyte levels (sodium and potassium) to ensure the dose is exactly right for your pet. Contact your vet if you notice excessive drinking, excessive urination, vomiting, or lethargy.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
Veterinary professional? See the full dosing-by-species reference on VetSheet →
What it is used for
- Primary hypoadrenocorticism (Addison's disease)
- Primary hypoadrenocorticism (Addison's disease)
How it is given
Possible side effects
- Pain on injection (rarely repeated in the same animal)
- Polyuria
- Polydipsia
- Hypokalaemia (with overdose)
- Vomiting
- Anorexia
- Muzzle swelling
- Anaphylaxis
Cautions & contraindications
- None strictly listed, but use with caution in congestive heart disease, severe renal disease, primary hepatic failure, or oedema
- > **Handling Precaution:** The vials are stable for several months once opened. Before use, shake gently to resuspend the product and continue to move the loaded syringe before injection to prevent precipitation.
Drug interactions
- Spironolactone: Aldosterone antagonist; counteracts the effects of desoxycortone
- Furosemide: May excessively reduce potassium levels
- Thiazides: May excessively reduce potassium levels
Frequently asked questions
What is Desoxycortone pivalate used for in pets?
This medication is a long-term replacement therapy for your pet's missing hormones. Do not miss doses. Regular blood tests will be required to check electrolyte levels (sodium and potassium) to ensure the dose is exactly right for your pet. Contact your vet if you notice excessive drinking, excessive urination, vomiting, or lethargy.
Is Desoxycortone pivalate safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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