唑尼沙胺
別名: Zonegran, Excegran
藥物類別: Anticonvulsant
* **嚴格遵守給藥時間**：請務必按照處方準時給藥，漏服可能導致癲癇發作。 * **切勿自行停藥**：突然停藥可能引發嚴重的「反彈性」癲癇。在調整劑量前請務必諮詢獸醫師。 * **癲癇日記**：請詳細記錄寵物癲癇發作的日期、時間、持續時間及嚴重程度，以協助獸醫師準確調整劑量。 * **副作用**：初期可能會出現輕微的嗜睡或步伐不穩，但通常會隨著寵物適應藥物而改善。如果寵物出現食慾不振、嘔吐或眼睛乾澀發紅，請立即聯繫獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Epilepsy (anecdotal)
- Refractory to phenobarbital
- Epilepsy
- Epilepsy
- Refractory epilepsy (with phenobarbital)
- Monotherapy
- Add-on with phenobarbital
- Initial monotherapy
- Add-on agent
- Epilepsy
- Epilepsy (monotherapy or adjunctive)
給藥方式
PORectal
可能的副作用
- Sedation (usually transient)
- Ataxia
- Inappetence / Anorexia
- Vomiting
- Diarrhea
- Somnolence
- Keratoconjunctivitis sicca (KCS) - theoretical risk due to sulfonamide structure
- Polyarthropathy or blood dyscrasias - theoretical risk due to sulfonamide structure
- Sedation
- Anorexia
- Keratoconjunctivitis sicca (KCS)
- Hepatotoxicity (rare)
- Metabolic acidosis
注意事項與禁忌
- Hypersensitivity to zonisamide
- Hypersensitivity to sulfonamide drugs
- Pregnancy (known teratogen in dogs)
- Hypersensitivity to sulfonamides
- Severe hepatic impairment
- > **Teratogenic Risk**: Zonisamide is a known teratogen in dogs. Doses of 10-30 mg/kg/day have caused ventricular septal defects, cardiomegaly, and valvular/arterial anomalies (threshold plasma level for malformation is 25 mcg/mL). Use in pregnant dogs carries significant risks. * **Sulfonamide Sensitivity**: Because it is a sulfonamide, monitor for idiosyncratic sulfonamide reactions (e.g., KCS, blood dyscrasias), though clinical reports in veterinary patients are currently rare. * Use with caution in nursing animals as it is unknown if it enters maternal milk.
藥物相互作用
- Phenobarbital: Increases the clearance of zonisamide. Repeated phenobarbital dosing decreases the bioavailability, peak concentrations, half-life, and AUC of zonisamide. This effect can persist up to 10 weeks after phenobarbital discontinuation. Higher zonisamide doses are typically required.
- Ketoconazole: May inhibit the hepatic metabolism of zonisamide, potentially increasing serum concentrations.
常見問題
唑尼沙胺用於寵物有什麼用途？
• 嚴格遵守給藥時間：請務必按照處方準時給藥，漏服可能導致癲癇發作。 • 切勿自行停藥：突然停藥可能引發嚴重的「反彈性」癲癇。在調整劑量前請務必諮詢獸醫師。 • 癲癇日記：請詳細記錄寵物癲癇發作的日期、時間、持續時間及嚴重程度，以協助獸醫師準確調整劑量。 • 副作用：初期可能會出現輕微的嗜睡或步伐不穩，但通常會隨著寵物適應藥物而改善。如果寵物出現食慾不振、嘔吐或眼睛乾澀發紅，請立即聯繫獸醫師。
唑尼沙胺對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。