維庫溴銨
別名: Norcuron, Curlem, Rivecrum, Vecural, Vecuron
藥物類別: Nondepolarizing Neuromuscular Blocker
此藥物僅限由獸醫專業人員在醫院環境中使用。 * **用途**：這是一種肌肉鬆弛劑，用於複雜手術期間，或當病患需要使用呼吸器協助呼吸時。 * **安全性**：在給予此藥物之前，您的寵物將處於完全睡眠（全身麻醉）狀態，對周圍環境毫無知覺。因為它會放鬆呼吸肌肉，獸醫團隊將在藥物作用期間使用機器協助您的寵物呼吸。 * **監測**：您的寵物將由受過訓練的專業人員持續監測，直到藥效消退且他們能夠舒適地自行呼吸為止。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Muscle relaxation during anesthesia
- Neuromuscular blockade (loading dose)
- Neuromuscular blockade (maintenance)
- Muscle relaxation during anesthesia
- Muscle relaxation during anesthesia
- Muscle relaxation (CRI maintenance with propofol-fentanyl)
- Muscle relaxation (CRI maintenance with fentanyl-isoflurane or fentanyl-sevoflurane)
- Neuromuscular blockade (loading dose)
- Neuromuscular blockade (maintenance)
- Reversal of neuromuscular blockade
給藥方式
IVtopicalintratracheal
可能的副作用
- Profound, prolonged musculoskeletal paralysis (pharmacologic effect)
- Skeletal muscle weakness
- Respiratory arrest (if mechanical ventilation is not provided)
- Prolonged apnea (expected pharmacological effect)
- No cardiovascular effects or histamine release reported at clinical doses
注意事項與禁忌
- Known hypersensitivity to vecuronium or bromides
- Conscious or inadequately anesthetized animals
- Lack of facilities for positive pressure ventilation/mechanical ventilation
- Severe hepatic dysfunction (relative contraindication; atracurium preferred)
- * **Ventilation Required**: Must only be used when facilities for intubation and mechanical ventilation are immediately available. * **Organ Dysfunction**: Use with caution in patients with severe **renal dysfunction**. Lower doses may be necessary in patients with **hepatic or biliary disease** due to delayed clearance and prolonged recovery times. * **Myasthenia Gravis**: Neuromuscular blocking agents should be used with extreme caution, if at all, in patients with myasthenia gravis (though one successful case in a dog has been reported). * **Pregnancy**: FDA Category C. Animal studies show adverse fetal effects, but adequate human/veterinary studies are lacking. Use only if benefits outweigh risks. * **No Analgesia**: Does not provide pain relief or sedation. Ensure adequate depth of anesthesia.
藥物相互作用
- Other Non-Depolarizing Muscle Relaxants: May have a synergistic effect if used concurrently with vecuronium.
- Succinylcholine: May speed the onset of action and enhance the neuromuscular blocking actions of vecuronium; do not give vecuronium until succinylcholine effects have subsided.
- Aminoglycosides: May enhance or prolong the neuromuscular blocking activity.
- Inhalant Anesthetics (Halothane, Isoflurane, Sevoflurane): May enhance or prolong the neuromuscular blocking activity.
- Clindamycin, Lincomycin: May enhance or prolong the neuromuscular blocking activity.
- Dantrolene: May enhance or prolong the neuromuscular blocking activity.
- Magnesium Salts: May enhance or prolong the neuromuscular blocking activity.
- Piperacillin, Mezlocillin: May enhance or prolong the neuromuscular blocking activity.
- Quinidine: May enhance or prolong the neuromuscular blocking activity.
- Tetracyclines: May enhance or prolong the neuromuscular blocking activity.
- Verapamil: May enhance or prolong the neuromuscular blocking activity.
- Volatile anaesthetics: Prolonged neuromuscular blockade
- Clindamycin: Prolonged neuromuscular blockade
- Lincomycin: Prolonged neuromuscular blockade
常見問題
維庫溴銨用於寵物有什麼用途？
此藥物僅限由獸醫專業人員在醫院環境中使用。 • 用途：這是一種肌肉鬆弛劑，用於複雜手術期間，或當病患需要使用呼吸器協助呼吸時。 • 安全性：在給予此藥物之前，您的寵物將處於完全睡眠（全身麻醉）狀態，對周圍環境毫無知覺。因為它會放鬆呼吸肌肉，獸醫團隊將在藥物作用期間使用機器協助您的寵物呼吸。 • 監測：您的寵物將由受過訓練的專業人員持續監測，直到藥效消退且他們能夠舒適地自行呼吸為止。
維庫溴銨對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。