Vecuronium Bromide
別名: Norcuron, Curlem, Rivecrum, Vecural, Vecuron
This medication is strictly for use by veterinary professionals in a hospital setting. * **Purpose**: It is a muscle relaxant used during complex surgeries or when a patient needs to be placed on a mechanical ventilator to help them breathe. * **Safety**: Your pet will be completely asleep (fully anesthetized) and unaware of their surroundings before this drug is given. Because it relaxes the breathing muscles, the veterinary team will use a machine to breathe for your pet while they are under its effects. * **Monitoring**: Your pet will be continuously monitored by trained professionals until the medication wears off and they can breathe comfortably on their own.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Muscle relaxation during anesthesia
- Neuromuscular blockade (loading dose)
- Neuromuscular blockade (maintenance)
- Muscle relaxation during anesthesia
- Muscle relaxation during anesthesia
- Muscle relaxation (CRI maintenance with propofol-fentanyl)
- Muscle relaxation (CRI maintenance with fentanyl-isoflurane or fentanyl-sevoflurane)
- Neuromuscular blockade (loading dose)
- Neuromuscular blockade (maintenance)
- Reversal of neuromuscular blockade
給藥方式
可能的副作用
- Profound, prolonged musculoskeletal paralysis (pharmacologic effect)
- Skeletal muscle weakness
- Respiratory arrest (if mechanical ventilation is not provided)
- Prolonged apnea (expected pharmacological effect)
- No cardiovascular effects or histamine release reported at clinical doses
注意事項與禁忌
- Known hypersensitivity to vecuronium or bromides
- Conscious or inadequately anesthetized animals
- Lack of facilities for positive pressure ventilation/mechanical ventilation
- Severe hepatic dysfunction (relative contraindication; atracurium preferred)
- * **Ventilation Required**: Must only be used when facilities for intubation and mechanical ventilation are immediately available. * **Organ Dysfunction**: Use with caution in patients with severe **renal dysfunction**. Lower doses may be necessary in patients with **hepatic or biliary disease** due to delayed clearance and prolonged recovery times. * **Myasthenia Gravis**: Neuromuscular blocking agents should be used with extreme caution, if at all, in patients with myasthenia gravis (though one successful case in a dog has been reported). * **Pregnancy**: FDA Category C. Animal studies show adverse fetal effects, but adequate human/veterinary studies are lacking. Use only if benefits outweigh risks. * **No Analgesia**: Does not provide pain relief or sedation. Ensure adequate depth of anesthesia.
藥物相互作用
- Other Non-Depolarizing Muscle Relaxants: May have a synergistic effect if used concurrently with vecuronium.
- Succinylcholine: May speed the onset of action and enhance the neuromuscular blocking actions of vecuronium; do not give vecuronium until succinylcholine effects have subsided.
- Aminoglycosides: May enhance or prolong the neuromuscular blocking activity.
- Inhalant Anesthetics (Halothane, Isoflurane, Sevoflurane): May enhance or prolong the neuromuscular blocking activity.
- Clindamycin, Lincomycin: May enhance or prolong the neuromuscular blocking activity.
- Dantrolene: May enhance or prolong the neuromuscular blocking activity.
- Magnesium Salts: May enhance or prolong the neuromuscular blocking activity.
- Piperacillin, Mezlocillin: May enhance or prolong the neuromuscular blocking activity.
- Quinidine: May enhance or prolong the neuromuscular blocking activity.
- Tetracyclines: May enhance or prolong the neuromuscular blocking activity.
常見問題
Vecuronium Bromide用於寵物有甚麼用途？
This medication is strictly for use by veterinary professionals in a hospital setting. * **Purpose**: It is a muscle relaxant used during complex surgeries or when a patient needs to be placed on a mechanical ventilator to help them breathe. * **Safety**: Your pet will be completely asleep (fully anesthetized) and unaware of their surroundings before this drug is given. Because it relaxes the breathing muscles, the veterinary team will use a machine to breathe for your pet while they are under its effects. * **Monitoring**: Your pet will be continuously monitored by trained professionals until the medication wears off and they can breathe comfortably on their own.
Vecuronium Bromide對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。