琥珀膽鹼

用途

• Muscle relaxation
• Muscle relaxation
• Muscle relaxation
• Muscle relaxation
• Muscle relaxation
• To relax an animal to allow intubation

給藥方式

可能的副作用

• Muscle soreness
• Histamine release
• Malignant hyperthermia
• Excessive salivation
• Hyperkalemia
• Rash
• Myoglobinemia
• Myoglobinuria
• Bradycardia
• Tachycardia
• Hypertension
• Hypotension
• Arrhythmias

注意事項與禁忌

• Severe liver disease
• Chronic anemias
• Chronic malnourishment
• Glaucoma or penetrating eye injuries
• Predisposition to malignant hyperthermia
• Increased CPK values with resultant myopathies
• Recent use of organophosphate agents
• > **CRITICAL WARNING:** Succinylcholine has NO analgesic or anesthetic effects. It must be used with appropriate analgesic, sedative, and anesthetic agents. Mechanical ventilation is required. * **Hyperkalemia Risk:** Use with extreme caution in patients with traumatic wounds, burns, preexisting hyperkalemia, or electrolyte imbalances, as fatal arrhythmias or cardiac arrest may occur due to sudden potassium efflux from muscle cells. * **Organ Dysfunction:** Use with caution in patients with pulmonary, renal, cardiovascular, metabolic, or hepatic dysfunction. * **Equine Specifics (AAEP Recommendations):** Inform owners it is a restraining agent, not an anesthetic. Do not use if the horse has received 'mycin' antibiotics, organophosphates, cholinesterase inhibitors, or procaine within 30 days. Do not use in debilitated/exhausted horses. Withhold food 4-6 hours prior. Be prepared to administer oxygen and artificial respiration. Have a handler prevent the horse from falling forward.

藥物相互作用

• Amphotericin B: May increase succinylcholine's effects by causing electrolyte imbalances
• Digoxin: Succinylcholine may cause a sudden outflux of potassium from muscle cells, causing arrhythmias in digitalized patients
• Opiates: Potential for increased incidences of bradycardia and sinus arrest
• Thiazide Diuretics: May increase succinylcholine's effects by causing electrolyte imbalances
• Aminoglycosides: May increase or prolong neuromuscular blockade
• Inhalant Anesthetics (Isoflurane, Desflurane): May increase or prolong neuromuscular blockade
• Antiarrhythmics (Quinidine, Lidocaine, Procainamide): May increase or prolong neuromuscular blockade
• Beta-Adrenergic Blockers: May increase or prolong neuromuscular blockade
• Corticosteroids: May increase or prolong neuromuscular blockade
• Magnesium Salts: May increase or prolong neuromuscular blockade
• Organophosphates: May increase or prolong neuromuscular blockade (Contraindicated)

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