多殺菌素

用途

• Flea infestation
• Prevention or treatment of fleas infestations
• Flea infestation

給藥方式

可能的副作用

• Vomiting (most common)
• Depression/lethargy
• Anorexia
• Ataxia
• Diarrhea
• Pruritus
• Trembling
• Hypersalivation
• Seizures (rare)
• Vomiting (occasional)
• Lethargy (rare)
• Diarrhoea (rare)
• Anorexia (rare)
• Ataxia (rare)

注意事項與禁忌

• Cats (per this specific monograph's label status)
• Dogs with known pork or soy allergies (chewable tablets contain pork proteins and hydrolyzed soy)
• Dogs and cats weighing < 1.2 kg
• Dogs and cats < 14 weeks of age
• Dogs with MDR1 mutation (relative contraindication due to increased risk of adverse effects)
• Use with caution in **breeding females** and dogs with **pre-existing epilepsy**, as higher than labeled dosages may decrease the seizure threshold. Safe use in breeding males has not been evaluated. The chewable tablets contain pork proteins and hydrolyzed soy; use cautiously in dogs with severe food allergies to these ingredients.

藥物相互作用

• Ivermectin: Concurrent use with high extra-label doses of ivermectin (e.g., for demodicosis) increases the risk of neurotoxicity. However, spinosad is safe to use with standard low-dose heartworm preventatives.
• Macrocyclic lactones (e.g., avermectins, ivermectin): Increased risk of severe neurological toxicity. Do not use in combination.
• Digoxin: Competition for P-glycoprotein efflux pump, potentially increasing digoxin levels.
• Doxorubicin: Competition for P-glycoprotein efflux pump, potentially increasing doxorubicin toxicity.

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