普魯卡因胺
別名: Pronestyl, Procan, Procanbid, Biocoryl
藥物類別: Antiarrhythmic (Class 1A)
* **給藥方式：** 口服藥物應在白天和夜間以平均間隔的時間給予，以維持穩定的血液濃度。 * **餵食：** 除非獸醫師另有指示，否則請在動物空腹時（至少飯前 1 小時）給予藥物。 * **監測：** 如果您寵物的病情惡化，或出現中毒的臨床症狀（例如：嘔吐、腹瀉、嚴重嗜睡或虛弱），請立即通知您的獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Chronic management of SVTs
- Chronic management of SVTs
- Chronic management of SVTs
- Atrial fibrillation / Ventricular tachycardia
- Atrial fibrillation / Ventricular tachycardia
- V-Tach
- Ventricular tachyarrhythmias
- Ventricular tachyarrhythmias
- Acute management of SVTs
- Chronic management of SVTs
- Acute treatment of ventricular tachycardia
- Chronic treatment of ventricular tachycardia
- Ventricular tachycardia
給藥方式
IVIMPO
可能的副作用
- Anorexia
- Vomiting
- Diarrhea
- Weakness
- Hypotension (especially with rapid IV injection)
- Negative inotropism
- Widened QRS complex
- Prolonged QT interval
- AV block
- Multiform ventricular tachycardias
- Fevers
- Leukopenias
注意事項與禁忌
- Myasthenia gravis
- Hypersensitivity to procainamide, procaine, or chemically related drugs
- Systemic lupus erythematosus (SLE) in humans (unknown in dogs)
- Torsade de pointes
- 2nd or 3rd degree heart block (unless artificially paced)
- Doberman pinschers and boxers with dilated cardiomyopathy (relative - proarrhythmic risk)
- Dogs with subaortic stenosis (relative - proarrhythmic risk)
- Use with **extreme caution** in patients with cardiac glycoside intoxication. Use with caution in patients with significant hepatic or renal disease, or congestive heart failure (CHF). Dosages should usually be reduced in patients with renal failure, CHF, or those who are critically ill. > **Warning:** Profound hypotension can occur if injected too rapidly IV. Do not use in Doberman pinschers and boxers with dilated cardiomyopathy or dogs with subaortic stenosis as it may be proarrhythmic and induce sudden death.
藥物相互作用
- Amiodarone: May increase procainamide levels; procainamide dose may need to be reduced
- Anticholinesterase agents (e.g., pyridostigmine, neostigmine): Procainamide may antagonize effects in patients with myasthenia gravis
- Cimetidine: May increase procainamide levels
- Hypotensive drugs: Procainamide may enhance hypotensive effects
- Lidocaine: Toxic effects may be additive, and cardiac effects unpredictable
- Neuromuscular blocking agents: Procainamide may potentiate or prolong the neuromuscular blocking activity
- Quinidine: Toxic effects may be additive, and cardiac effects unpredictable
- Phenytoin: Toxic effects may be additive, and cardiac effects unpredictable
- Propranolol: Toxic effects may be additive, and cardiac effects unpredictable
- Ranitidine: May increase procainamide levels
- Trimethoprim: May increase procainamide levels
常見問題
普魯卡因胺用於寵物有什麼用途？
* **給藥方式：** 口服藥物應在白天和夜間以平均間隔的時間給予，以維持穩定的血液濃度。 * **餵食：** 除非獸醫師另有指示，否則請在動物空腹時（至少飯前 1 小時）給予藥物。 * **監測：** 如果您寵物的病情惡化，或出現中毒的臨床症狀（例如：嘔吐、腹瀉、嚴重嗜睡或虛弱），請立即通知您的獸醫師。
普魯卡因胺對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。