普瑞巴林

用途

• Seizure disorders (anecdotal)
• Seizure disorders (PK theory)
• Neuropathic pain and seizures (extrapolated from PK study)
• Seizure disorders
• Seizure disorders
• Refractory seizures (adjunct therapy)

給藥方式

可能的副作用

• Sedation
• Ataxia
• Somnolence
• Dizziness
• Difficulty with concentration/attention/memory
• Blurred vision
• Dry mouth
• Peripheral edema
• Constipation
• Weight gain
• Syncope
• Congestive heart failure
• Renal failure (reversible)
• Rhabdomyolysis
• Hypersensitivity reactions (angioedema, rash, blisters, wheezing)

注意事項與禁忌

• Hypersensitivity to pregabalin
• Pregnant animals (toxicity demonstrated in experimental studies)
• Abrupt discontinuation
• Use with caution in patients with renal insufficiency; dosage adjustment should be considered (in humans, adjusted based on creatinine clearance). Use with caution in patients with heart failure. Abrupt discontinuation may lead to increased seizure frequency, diarrhea, headache, insomnia, or nausea. Weigh potential risks versus benefits in pregnant or nursing animals (FDA Category C in humans; very high dosages have caused skeletal malformations in rats and rabbits).

藥物相互作用

• ACE Inhibitors (e.g., benazepril, enalapril): In humans, coadministration may increase risks of edema and hives.
• CNS Depressants: May cause additive CNS depression.
• NSAIDs (e.g., ketorolac, naproxen): In humans, cited as possibly reducing anticonvulsant effectiveness, though substantive evidence is weak.

常見問題