Pregabalin
別名: Lyrica, CI-1008, PD-144723, Alzain, Axalid
* **What to Expect**: The most common side effects seen in animals are sleepiness (sedation) and sometimes difficulty walking (ataxia). If these are severe or persist, contact your veterinarian. * **Important Warnings**: > **Do not stop abruptly!** Suddenly stopping pregabalin without your veterinarian's approval may cause increased adverse effects and can trigger severe seizures in epileptic patients. Always taper the dose under veterinary guidance. * **Allergic Reactions**: Although rare, if you notice a rash, hives, facial swelling, wheezing, or collapse, contact your veterinarian immediately. * **Administration**: Can be given with or without food. If using the liquid form, discard any unused portion 45 days after opening.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Seizure disorders (anecdotal)
- Seizure disorders (PK theory)
- Neuropathic pain and seizures (extrapolated from PK study)
- Seizure disorders
- Seizure disorders
- Refractory seizures (adjunct therapy)
給藥方式
可能的副作用
- Sedation
- Ataxia
- Somnolence
- Dizziness
- Difficulty with concentration/attention/memory
- Blurred vision
- Dry mouth
- Peripheral edema
- Constipation
- Weight gain
- Syncope
- Congestive heart failure
- Renal failure (reversible)
- Rhabdomyolysis
- Hypersensitivity reactions (angioedema, rash, blisters, wheezing)
注意事項與禁忌
- Hypersensitivity to pregabalin
- Pregnant animals (toxicity demonstrated in experimental studies)
- Abrupt discontinuation
- Use with caution in patients with renal insufficiency; dosage adjustment should be considered (in humans, adjusted based on creatinine clearance). Use with caution in patients with heart failure. Abrupt discontinuation may lead to increased seizure frequency, diarrhea, headache, insomnia, or nausea. Weigh potential risks versus benefits in pregnant or nursing animals (FDA Category C in humans; very high dosages have caused skeletal malformations in rats and rabbits).
藥物相互作用
- ACE Inhibitors (e.g., benazepril, enalapril): In humans, coadministration may increase risks of edema and hives.
- CNS Depressants: May cause additive CNS depression.
- NSAIDs (e.g., ketorolac, naproxen): In humans, cited as possibly reducing anticonvulsant effectiveness, though substantive evidence is weak.
常見問題
Pregabalin用於寵物有甚麼用途？
* **What to Expect**: The most common side effects seen in animals are sleepiness (sedation) and sometimes difficulty walking (ataxia). If these are severe or persist, contact your veterinarian. * **Important Warnings**: > **Do not stop abruptly!** Suddenly stopping pregabalin without your veterinarian's approval may cause increased adverse effects and can trigger severe seizures in epileptic patients. Always taper the dose under veterinary guidance. * **Allergic Reactions**: Although rare, if you notice a rash, hives, facial swelling, wheezing, or collapse, contact your veterinarian immediately. * **Administration**: Can be given with or without food. If using the liquid form, discard any unused portion 45 days after opening.
Pregabalin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。