青黴胺
別名: Depen, Cuprimine, Pendramine
藥物類別: Antidote; Chelating Agent
此藥物主要用於幫助您的寵物排出體內過多的金屬（如銅或鉛），或溶解特定類型的膀胱結石。 * **給藥方式**：最好在**空腹**時給藥（餵食前至少30分鐘），以確保藥物被充分吸收。 * **副作用管理**：如果您的寵物出現嘔吐或食慾不振，請聯繫獸醫。他們可能會建議：將每日劑量分成更小、更頻繁的劑量；暫時減少劑量；或與少量食物（如起司或麵包）一起餵食以減少腸胃不適。 * **請勿**將此藥物與維生素/礦物質補充劑（特別是含鋅或鐵的產品）或制酸劑同時餵食，因為它們會與藥物結合並使其失效。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Lead poisoning
- Copper toxicity
- Copper toxicity
- Lead or mercury toxicity
- Adjunctive treatment of lead poisoning
- Lead or mercury toxicity
- Copper toxicity
- Copper toxicity
- Lead or mercury toxicity
- Copper-associated hepatopathy
- Copper-associated hepatopathy
- Copper-associated hepatopathy
- Copper-associated hepatopathy
- Cystine urolithiasis
給藥方式
PO
可能的副作用
- Nausea
- Vomiting
- Depression
- Anorexia
- Dietary mineral deficiencies (zinc, iron, copper, calcium) with long-term use
- Fever (rare)
- Lymphadenopathy (rare)
- Skin hypersensitivity reactions (rare)
- Immune-complex glomerulonephropathy (rare)
- Teratogenicity
- Pyrexia
- Nephrotic syndrome
- Leucopenia (human data)
- Thrombocytopenia (human data)
注意事項與禁忌
- Patients with a history of penicillamine-related blood dyscrasias
- Presence of lead in the gastrointestinal tract (can enhance absorption)
- Pregnancy (unless benefits outweigh teratogenic risks)
- Moderate to marked renal impairment
- History of penicillamine-related blood dyscrasias
- Penicillamine is contraindicated in patients with a history of penicillamine-related blood dyscrasias. **Warning**: Penicillamine potentially can cause enhanced absorption of lead from the gastrointestinal tract. If lead is still present in the gut (e.g., visible on radiographs), it should NOT be administered until the GI tract is cleared. Use with caution in pregnant animals due to known teratogenic potential (FDA Category D).
藥物相互作用
- 4-Aminoquinoline drugs (e.g., chloroquine, quinacrine): Concomitant administration may increase the risks for severe dermatologic adverse effects.
- Oral Cations (Zinc, Iron, Calcium, Magnesium): May decrease the effectiveness of penicillamine if given orally together due to chelation in the gut.
- Food and Antacids: The amount of penicillamine absorbed from the GI tract may be reduced by concurrent administration.
- Gold Compounds: May increase the risk of hematologic and/or renal adverse reactions.
- Immunosuppressant drugs (e.g., cyclophosphamide, azathioprine): May increase the risk of hematologic and/or renal adverse reactions.
- Phenylbutazone: May increase the risk of hematologic and/or renal adverse reactions.
- Antacids: Decreased gastrointestinal absorption of penicillamine
- Food: Decreased gastrointestinal absorption of penicillamine
- Iron salts: Decreased gastrointestinal absorption of penicillamine
- Zinc salts: Decreased gastrointestinal absorption of penicillamine
常見問題
青黴胺用於寵物有什麼用途？
此藥物主要用於幫助您的寵物排出體內過多的金屬（如銅或鉛），或溶解特定類型的膀胱結石。 * **給藥方式**：最好在**空腹**時給藥（餵食前至少30分鐘），以確保藥物被充分吸收。 * **副作用管理**：如果您的寵物出現嘔吐或食慾不振，請聯繫獸醫。他們可能會建議：將每日劑量分成更小、更頻繁的劑量；暫時減少劑量；或與少量食物（如起司或麵包）一起餵食以減少腸胃不適。 * **請勿**將此藥物與維生素/礦物質補充劑（特別是含鋅或鐵的產品）或制酸劑同時餵食，因為它們會與藥物結合並使其失效。
青黴胺對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。