醋酸甲羥孕酮

用途

• Behavioral disorders (reduce marking in neutered males)
• Feline psychogenic alopecia and dermatitis
• Progestagen-responsive dermatitis
• Recurrent abortion secondary to progesterone-deficiency
• Long-term reproductive control
• Long-term reproductive control
• Management of spring transition, prevention of estrus behavior, induction of estrous cycle synchrony, pregnancy maintenance, modification of stallion behavior
• Antipruritic and to suppress ovulation
• Apparent luteal insufficiency in bitches
• Long-term reproductive control
• Adjunctive treatment of aggressive behaviors
• Young German shepherd dwarfs

給藥方式

可能的副作用

• Increased thirst (polydipsia) and urination (polyuria)
• Increased appetite (polyphagia) and weight gain
• Depression, lethargy, and personality changes
• Adrenocortical depression (HPA axis suppression)
• Mammary changes (enlargement, milk production, neoplasia)
• Diabetes mellitus
• Pyometra / Cystic endometrial hyperplasia
• Temporary inhibition of spermatogenesis
• Permanent local alopecia, skin atrophy, and depigmentation (with SC injection)
• Acromegaly (in dogs)

注意事項與禁忌

• Pre-pubescent cats or dogs
• Diabetes mellitus
• Pseudopregnant bitches
• Females in diestrus or with prolonged heat
• Uterine hemorrhage or discharge
• Pregnancy (unless specifically treating hypoluteoidism)
• Progestagen therapy can cause serious adverse effects; safer alternative treatments should be considered first. Do not use prior to puberty as severe mammary hypertrophy or subclinical uterine/endocrine conditions may result. Because this drug can suppress adrenal function, exogenous steroids may be needed during times of stress (e.g., surgery, trauma). Prior to reproductive use, perform a thorough history, physical exam, mammary palpation, and vaginal smear to rule out diestrus, estrus, or mammary nodules.

藥物相互作用

• Aminoglutethimide: May decrease medroxyprogesterone effects
• Felbamate: May increase medroxyprogesterone metabolism
• Rifampin: May decrease progestin activity due to microsomal enzyme induction and increased progestin metabolism

常見問題