Medroxyprogesterone Acetate
別名: Provera, Depo-Provera, depo-subQ provera 104
> **Important:** This medication carries significant risks and is typically only used when safer alternative treatments have failed. * **Monitor closely** for increased thirst, increased urination, or increased appetite. These can be early signs of **diabetes mellitus**, a serious potential side effect. * Watch for any changes in the mammary glands, such as swelling, lumps, or milk production. * In intact (unspayed) females, monitor for signs of a severe uterine infection (**pyometra**), which may include lethargy, vomiting, decreased appetite, or vaginal discharge. Seek veterinary care immediately if these occur. * If given by injection under the skin, it may cause permanent hair loss, skin thinning, or color changes at the injection site. * Your pet may experience personality changes, lethargy, or weight gain while on this medication.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Behavioral disorders (reduce marking in neutered males)
- Feline psychogenic alopecia and dermatitis
- Progestagen-responsive dermatitis
- Recurrent abortion secondary to progesterone-deficiency
- Long-term reproductive control
- Long-term reproductive control
- Management of spring transition, prevention of estrus behavior, induction of estrous cycle synchrony, pregnancy maintenance, modification of stallion behavior
- Antipruritic and to suppress ovulation
- Apparent luteal insufficiency in bitches
- Long-term reproductive control
- Adjunctive treatment of aggressive behaviors
- Young German shepherd dwarfs
給藥方式
可能的副作用
- Increased thirst (polydipsia) and urination (polyuria)
- Increased appetite (polyphagia) and weight gain
- Depression, lethargy, and personality changes
- Adrenocortical depression (HPA axis suppression)
- Mammary changes (enlargement, milk production, neoplasia)
- Diabetes mellitus
- Pyometra / Cystic endometrial hyperplasia
- Temporary inhibition of spermatogenesis
- Permanent local alopecia, skin atrophy, and depigmentation (with SC injection)
- Acromegaly (in dogs)
注意事項與禁忌
- Pre-pubescent cats or dogs
- Diabetes mellitus
- Pseudopregnant bitches
- Females in diestrus or with prolonged heat
- Uterine hemorrhage or discharge
- Pregnancy (unless specifically treating hypoluteoidism)
- Progestagen therapy can cause serious adverse effects; safer alternative treatments should be considered first. Do not use prior to puberty as severe mammary hypertrophy or subclinical uterine/endocrine conditions may result. Because this drug can suppress adrenal function, exogenous steroids may be needed during times of stress (e.g., surgery, trauma). Prior to reproductive use, perform a thorough history, physical exam, mammary palpation, and vaginal smear to rule out diestrus, estrus, or mammary nodules.
藥物相互作用
- Aminoglutethimide: May decrease medroxyprogesterone effects
- Felbamate: May increase medroxyprogesterone metabolism
- Rifampin: May decrease progestin activity due to microsomal enzyme induction and increased progestin metabolism
常見問題
Medroxyprogesterone Acetate用於寵物有甚麼用途？
> **Important:** This medication carries significant risks and is typically only used when safer alternative treatments have failed. * **Monitor closely** for increased thirst, increased urination, or increased appetite. These can be early signs of **diabetes mellitus**, a serious potential side effect. * Watch for any changes in the mammary glands, such as swelling, lumps, or milk production. * In intact (unspayed) females, monitor for signs of a severe uterine infection (**pyometra**), which may include lethargy, vomiting, decreased appetite, or vaginal discharge. Seek veterinary care immediately if these occur. * If given by injection under the skin, it may cause permanent hair loss, skin thinning, or color changes at the injection site. * Your pet may experience personality changes, lethargy, or weight gain while on this medication.
Medroxyprogesterone Acetate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。