酮洛芬
別名: Ketofen, Anafen, Comforion Vet
酮洛芬 (Ketoprofen) 是一種用於減輕寵物疼痛、發炎和發燒的藥物。 **重要安全指引：** * **與食物一起服用**：如果您是口服給予酮洛芬，最好與食物一起餵食，以幫助減少腸胃不適的機會。 * **注意腸胃問題**：最常見的副作用是嘔吐、食慾不振和腹瀉。如果您的寵物嘔吐、停止進食，或者您發現有黑色柏油狀糞便或嘔吐物/糞便中有血，**請立即停止給藥並聯繫您的獸醫師**。這些可能是胃潰瘍的徵兆。 * **請勿混合用藥**：除非獸醫師特別指示，否則在寵物服用酮洛芬期間，**絕對不要**給予阿斯匹靈、布洛芬或其他止痛藥（如 Rimadyl、Metacam 或 Deramaxx）。混合使用這些藥物可能會導致致命的胃出血或腎衰竭。 * **嚴格遵守指示**：請勿自行增加劑量或增加給藥頻率。犬貓對 NSAID 的過量非常敏感。 * **保持水分充足**：確保您的寵物隨時有充足的新鮮飲水，這有助於保護牠們的腎臟。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Antiinflammatory/analgesic
- Antiinflammatory/analgesic
- Post-operative pain control
- Antiinflammatory/analgesic
- Acute pain from musculoskeletal and other painful disorders
- Acute pain from musculoskeletal and other painful disorders
- Antiinflammatory/analgesic
- Post-operative analgesic
- Labeled indications (inflammation and pain)
- Adjunctive treatment for laminitis
- Antiinflammatory analgesic
- Antiinflammatory analgesic
- Chronic pain/antiinflammatory (Rabbits)
- Analgesia (Rats)
- Analgesia (Rabbits)
- Antiinflammatory/analgesic
- Antiinflammatory/analgesic
- Antiinflammatory/analgesic
- Post-operative pain control
- Post-operative pain control
- Acute indications
- Chronic pain
- Acute pain from musculoskeletal and other painful disorders
- Management of chronic pain from osteoarthritis
- Acute pain from musculoskeletal and other painful disorders
給藥方式
可能的副作用
- Horses: Gastric mucosal damage, GI ulceration, renal crest necrosis, mild hepatitis, injection site inflammation (IM)
- Dogs and Cats: Vomiting, anorexia, gastrointestinal ulceration, renal toxicity
- General: Masking of infection signs (inflammation, hyperpyrexia)
- Gastrointestinal signs (vomiting, diarrhea, anorexia)
- Gastrointestinal ulceration and bleeding
- Renal toxicity (especially in dehydrated/hypotensive patients)
- Hepatic accumulation (in patients with liver disease)
- Potential precipitation of cardiac failure (rare/unknown risk in animals)
注意事項與禁忌
- Known hypersensitivity to ketoprofen or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Significant renal or hepatic impairment
- Late pregnancy (due to risk of premature closure of the patent ductus arteriosus)
- Intra-arterial administration
- Dehydrated, hypovolaemic, or hypotensive patients
- Patients with pre-existing gastrointestinal disease
- Patients with blood clotting problems
- Pregnant animals
- Animals < 6 weeks of age
- > **High Protein Binding**: Because ketoprofen is highly protein-bound, patients with hypoproteinemia may have increased levels of free (active) drug, significantly increasing the risk of toxicity. * **GI and Renal Risks**: Use only when potential benefits outweigh risks in patients with a history of GI ulceration or compromised renal/hepatic function. * **Masking Infection**: May mask clinical signs of infection such as fever and inflammation. Use appropriate anti-infective therapy if a primary infectious process is present. * **Breeding Animals**: Use with caution in breeding animals; effects on fertility and fetal health are not fully established. Avoid in late pregnancy. * **Administration Warnings**: Avoid subcutaneous (SC) injections in horses. Do not administer intra-arterially in any species.
藥物相互作用
- Aminoglycosides (gentamicin, amikacin): Increased risk for nephrotoxicity.
- Anticoagulants (heparin, LMWH, warfarin): Increased risk for bleeding.
- Aspirin: Plasma levels of ketoprofen could decrease; increased likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
- Bisphosphonates (alendronate): May increase risk for GI ulceration.
- Corticosteroids: Concomitant administration significantly increases the risks for GI adverse effects and ulceration.
- Cyclosporine: May increase risk for nephrotoxicity.
- Fluconazole: May increase NSAID levels.
- Furosemide: Ketoprofen may reduce the saluretic and diuretic effects of furosemide.
- Highly Protein Bound Drugs (phenytoin, valproic acid, sulfonamides): Ketoprofen is 99% protein-bound and may displace other drugs, leading to increased serum levels and duration of action.
- Methotrexate: Serious toxicity has occurred when NSAIDs are used concomitantly; use with extreme caution.
- Probenecid: May cause a significant increase in serum levels and half-life of ketoprofen.
- Other NSAIDs: Increased risk of severe gastrointestinal ulceration and renal toxicity. Do not administer concurrently or within 24 hours.
- Glucocorticoids: Increased risk of severe gastrointestinal ulceration and bleeding. Do not administer concurrently or within 24 hours.
- Aminoglycosides: Increased risk of nephrotoxicity.
常見問題
酮洛芬用於寵物有什麼用途？
酮洛芬 (Ketoprofen) 是一種用於減輕寵物疼痛、發炎和發燒的藥物。 重要安全指引： • 與食物一起服用：如果您是口服給予酮洛芬，最好與食物一起餵食，以幫助減少腸胃不適的機會。 • 注意腸胃問題：最常見的副作用是嘔吐、食慾不振和腹瀉。如果您的寵物嘔吐、停止進食，或者您發現有黑色柏油狀糞便或嘔吐物/糞便中有血，請立即停止給藥並聯繫您的獸醫師。這些可能是胃潰瘍的徵兆。 • 請勿混合用藥：除非獸醫師特別指示，否則在寵物服用酮洛芬期間，絕對不要給予阿斯匹靈、布洛芬或其他止痛藥（如 Rimadyl、Metacam 或 Deramaxx）。混合使用這些藥物可能會導致致命的胃出血或腎衰竭。 • 嚴格遵守指示：請勿自行增加劑量或增加給藥頻率。犬貓對 NSAID 的過量非常敏感。 • 保持水分充足：確保您的寵物隨時有充足的新鮮飲水，這有助於保護牠們的腎臟。
酮洛芬對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。