Ketoprofen
別名: Ketofen, Anafen, Comforion Vet
Ketoprofen is a medication used to reduce pain, inflammation, and fever in your pet. **Important Safety Guidelines:** * **Give with Food**: If you are giving ketoprofen by mouth, it is best to give it with a meal to help reduce the chance of stomach upset. * **Watch for Stomach Issues**: The most common side effects are vomiting, loss of appetite, and diarrhea. **Stop giving the medication and contact your veterinarian immediately** if your pet vomits, stops eating, or if you notice dark, tarry stools or blood in their vomit or feces. These can be signs of stomach ulcers. * **Do Not Mix Medications**: **Never** give your pet aspirin, ibuprofen, or any other pain relievers (like Rimadyl, Metacam, or Deramaxx) while they are taking ketoprofen unless specifically instructed by your veterinarian. Mixing these can cause fatal stomach bleeding or kidney failure. * **Follow Instructions Exactly**: Do not increase the dose or give it more frequently than prescribed. Cats and dogs are very sensitive to NSAID overdoses. * **Hydration is Key**: Ensure your pet always has access to plenty of fresh drinking water to help protect their kidneys.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Antiinflammatory/analgesic
- Antiinflammatory/analgesic
- Post-operative pain control
- Antiinflammatory/analgesic
- Acute pain from musculoskeletal and other painful disorders
- Acute pain from musculoskeletal and other painful disorders
- Antiinflammatory/analgesic
- Post-operative analgesic
- Labeled indications (inflammation and pain)
- Adjunctive treatment for laminitis
- Antiinflammatory analgesic
- Antiinflammatory analgesic
- Chronic pain/antiinflammatory (Rabbits)
給藥方式
可能的副作用
- Horses: Gastric mucosal damage, GI ulceration, renal crest necrosis, mild hepatitis, injection site inflammation (IM)
- Dogs and Cats: Vomiting, anorexia, gastrointestinal ulceration, renal toxicity
- General: Masking of infection signs (inflammation, hyperpyrexia)
- Gastrointestinal signs (vomiting, diarrhea, anorexia)
- Gastrointestinal ulceration and bleeding
- Renal toxicity (especially in dehydrated/hypotensive patients)
- Hepatic accumulation (in patients with liver disease)
- Potential precipitation of cardiac failure (rare/unknown risk in animals)
注意事項與禁忌
- Known hypersensitivity to ketoprofen or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Significant renal or hepatic impairment
- Late pregnancy (due to risk of premature closure of the patent ductus arteriosus)
- Intra-arterial administration
- Dehydrated, hypovolaemic, or hypotensive patients
- Patients with pre-existing gastrointestinal disease
- Patients with blood clotting problems
- Pregnant animals
- Animals < 6 weeks of age
- > **High Protein Binding**: Because ketoprofen is highly protein-bound, patients with hypoproteinemia may have increased levels of free (active) drug, significantly increasing the risk of toxicity. * **GI and Renal Risks**: Use only when potential benefits outweigh risks in patients with a history of GI ulceration or compromised renal/hepatic function. * **Masking Infection**: May mask clinical signs of infection such as fever and inflammation. Use appropriate anti-infective therapy if a primary infectious process is present. * **Breeding Animals**: Use with caution in breeding animals; effects on fertility and fetal health are not fully established. Avoid in late pregnancy. * **Administration Warnings**: Avoid subcutaneous (SC) injections in horses. Do not administer intra-arterially in any species.
藥物相互作用
- Aminoglycosides (gentamicin, amikacin): Increased risk for nephrotoxicity.
- Anticoagulants (heparin, LMWH, warfarin): Increased risk for bleeding.
- Aspirin: Plasma levels of ketoprofen could decrease; increased likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
- Bisphosphonates (alendronate): May increase risk for GI ulceration.
- Corticosteroids: Concomitant administration significantly increases the risks for GI adverse effects and ulceration.
- Cyclosporine: May increase risk for nephrotoxicity.
- Fluconazole: May increase NSAID levels.
- Furosemide: Ketoprofen may reduce the saluretic and diuretic effects of furosemide.
- Highly Protein Bound Drugs (phenytoin, valproic acid, sulfonamides): Ketoprofen is 99% protein-bound and may displace other drugs, leading to increased serum levels and duration of action.
- Methotrexate: Serious toxicity has occurred when NSAIDs are used concomitantly; use with extreme caution.
常見問題
Ketoprofen用於寵物有甚麼用途？
Ketoprofen is a medication used to reduce pain, inflammation, and fever in your pet. **Important Safety Guidelines:** * **Give with Food**: If you are giving ketoprofen by mouth, it is best to give it with a meal to help reduce the chance of stomach upset. * **Watch for Stomach Issues**: The most common side effects are vomiting, loss of appetite, and diarrhea. **Stop giving the medication and contact your veterinarian immediately** if your pet vomits, stops eating, or if you notice dark, tarry stools or blood in their vomit or feces. These can be signs of stomach ulcers. * **Do Not Mix Medications**: **Never** give your pet aspirin, ibuprofen, or any other pain relievers (like Rimadyl, Metacam, or Deramaxx) while they are taking ketoprofen unless specifically instructed by your veterinarian. Mixing these can cause fatal stomach bleeding or kidney failure. * **Follow Instructions Exactly**: Do not increase the dose or give it more frequently than prescribed. Cats and dogs are very sensitive to NSAID overdoses. * **Hydration is Key**: Ensure your pet always has access to plenty of fresh drinking water to help protect their kidneys.
Ketoprofen對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。