氟尿嘧啶
別名: Adrucil, Efudix, Fluorouracil, 5-FU
> **貓咪主人的嚴重警告**：含有 5-FU 的人類局部藥膏（用於皮膚病灶）對貓來說**具有劇毒且經常致命**。即使只是舔舐微量，或走過塗抹區域後理毛，都可能導致死亡。請務必將此類藥物放在貓咪絕對接觸不到的地方。 * **嚴重的副作用**：請了解這是一種強效的化療藥物。它可能導致嚴重的腸胃不適、骨髓抑制（增加感染風險）和神經系統症狀。 * **監測**：必須嚴格遵守回診抽血（全血細胞計數 CBC）的安排，以確保您寵物的白血球數量保持在安全範圍內。 * **居家安全**：因為此藥物是已知的致畸胎物（可能導致出生缺陷）且會排泄於體液中，孕婦、哺乳期婦女和兒童在治療後的幾天內應避免接觸藥物或寵物的排泄物（尿液/糞便）。清理排泄物時請戴上手套。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- ALL
- All indications
- Intratumoral injection with epinephrine into certain skin neoplasms (squamous cell carcinoma, melanoma, sarcoid)
- Canine mammary carcinoma (in combination with doxorubicin and cyclophosphamide-FAC protocol), dermal squamous cell carcinoma and GI tract tumors
- Systemic carcinomas
- Basal cell and squamous cell carcinoma
給藥方式
可能的副作用
- Dose-dependent myelosuppression (leukopenia, thrombocytopenia)
- Gastrointestinal toxicity (nausea, vomiting, hemorrhagic diarrhea, GI ulceration/sloughing, stomatitis)
- Neurotoxicity (ataxia, disorientation, seizures)
- Fatal neurotoxicity in cats (even with topical exposure)
- Anorexia
- Vomiting
- Stomatitis
- Diarrhoea
- Leucopenia (nadir between 7 and 14 days)
- Thrombocytopenia
- Anaemia
- Alopecia
- Hyperpigmentation
- Dermatitis
注意事項與禁忌
- CATS (Do NOT use in any form, including topical)
- Patients with known hypersensitivity to the drug
- Patients in poor nutritional states
- Patients with depressed or reduced bone marrow function
- Patients with concurrent serious infections
- Pregnancy (Known teratogen - FDA Category D)
- Cats (strictly contraindicated due to fatal neurotoxicity)
- Patients with severe bone marrow suppression
- Patients with severe hepatic or renal impairment (unless dose is adjusted)
- Pregnancy and lactation
- Fluorouracil has a very narrow therapeutic index and should only be administered by clinicians experienced with cancer chemotherapeutic agents. **Feline Toxicity**: Cats develop severe, potentially fatal neurotoxicity. It is contraindicated in cats in any form. **Reproductive Safety**: 5-FU is a known teratogen. Pregnant women and pregnant veterinary staff should avoid handling this medication or the bodily fluids/waste of treated animals. If a nursing dam requires treatment, milk replacer should be used as the drug inhibits DNA/RNA synthesis.
藥物相互作用
- Leucovorin: May increase the gastrointestinal toxic effects of 5-FU
- Cimetidine: Inhibits the metabolism of 5-FU, potentially increasing toxicity
- Carboplatin: Synergism in human oncology, but combination may be more toxic in small animals
- Methotrexate: Synergistic if administered before 5-FU; antagonistic if administered afterwards
- Vincristine: Increases the cytotoxicity of 5-FU
常見問題
氟尿嘧啶用於寵物有什麼用途？
> **貓咪主人的嚴重警告**：含有 5-FU 的人類局部藥膏（用於皮膚病灶）對貓來說**具有劇毒且經常致命**。即使只是舔舐微量，或走過塗抹區域後理毛，都可能導致死亡。請務必將此類藥物放在貓咪絕對接觸不到的地方。 * **嚴重的副作用**：請了解這是一種強效的化療藥物。它可能導致嚴重的腸胃不適、骨髓抑制（增加感染風險）和神經系統症狀。 * **監測**：必須嚴格遵守回診抽血（全血細胞計數 CBC）的安排，以確保您寵物的白血球數量保持在安全範圍內。 * **居家安全**：因為此藥物是已知的致畸胎物（可能導致出生缺陷）且會排泄於體液中，孕婦、哺乳期婦女和兒童在治療後的幾天內應避免接觸藥物或寵物的排泄物（尿液/糞便）。清理排泄物時請戴上手套。
氟尿嘧啶對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。