Fluorouracil
別名: Adrucil, Efudix, Fluorouracil, 5-FU
> **CRITICAL WARNING FOR CAT OWNERS**: Human topical creams containing 5-FU (used for skin lesions) are **highly toxic and frequently fatal** to cats. Even a tiny lick or walking across a treated area and grooming can cause death. Keep all such medications strictly out of reach. * **Serious Side Effects**: Understand that this is a potent chemotherapy drug. It can cause severe gastrointestinal upset, bone marrow suppression (increasing the risk of infection), and neurological signs. * **Monitoring**: Strict adherence to follow-up appointments for bloodwork (CBCs) is mandatory to ensure your pet's white blood cell counts remain safe. * **Safety at Home**: Because this drug is a known teratogen (can cause birth defects) and is excreted in bodily fluids, pregnant women, nursing mothers, and children should avoid handling the medication or the pet's waste (urine/feces) for several days post-treatment. Wear gloves when cleaning up accidents.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- ALL
- All indications
- Intratumoral injection with epinephrine into certain skin neoplasms (squamous cell carcinoma, melanoma, sarcoid)
- Canine mammary carcinoma (in combination with doxorubicin and cyclophosphamide-FAC protocol), dermal squamous cell carcinoma and GI tract tumors
- Systemic carcinomas
- Basal cell and squamous cell carcinoma
給藥方式
可能的副作用
- Dose-dependent myelosuppression (leukopenia, thrombocytopenia)
- Gastrointestinal toxicity (nausea, vomiting, hemorrhagic diarrhea, GI ulceration/sloughing, stomatitis)
- Neurotoxicity (ataxia, disorientation, seizures)
- Fatal neurotoxicity in cats (even with topical exposure)
- Anorexia
- Vomiting
- Stomatitis
- Diarrhoea
- Leucopenia (nadir between 7 and 14 days)
- Thrombocytopenia
- Anaemia
- Alopecia
- Hyperpigmentation
- Dermatitis
注意事項與禁忌
- CATS (Do NOT use in any form, including topical)
- Patients with known hypersensitivity to the drug
- Patients in poor nutritional states
- Patients with depressed or reduced bone marrow function
- Patients with concurrent serious infections
- Pregnancy (Known teratogen - FDA Category D)
- Cats (strictly contraindicated due to fatal neurotoxicity)
- Patients with severe bone marrow suppression
- Patients with severe hepatic or renal impairment (unless dose is adjusted)
- Pregnancy and lactation
- Fluorouracil has a very narrow therapeutic index and should only be administered by clinicians experienced with cancer chemotherapeutic agents. **Feline Toxicity**: Cats develop severe, potentially fatal neurotoxicity. It is contraindicated in cats in any form. **Reproductive Safety**: 5-FU is a known teratogen. Pregnant women and pregnant veterinary staff should avoid handling this medication or the bodily fluids/waste of treated animals. If a nursing dam requires treatment, milk replacer should be used as the drug inhibits DNA/RNA synthesis.
藥物相互作用
- Leucovorin: May increase the gastrointestinal toxic effects of 5-FU
- Cimetidine: Inhibits the metabolism of 5-FU, potentially increasing toxicity
- Carboplatin: Synergism in human oncology, but combination may be more toxic in small animals
- Methotrexate: Synergistic if administered before 5-FU; antagonistic if administered afterwards
- Vincristine: Increases the cytotoxicity of 5-FU
常見問題
Fluorouracil用於寵物有甚麼用途？
> **CRITICAL WARNING FOR CAT OWNERS**: Human topical creams containing 5-FU (used for skin lesions) are **highly toxic and frequently fatal** to cats. Even a tiny lick or walking across a treated area and grooming can cause death. Keep all such medications strictly out of reach. * **Serious Side Effects**: Understand that this is a potent chemotherapy drug. It can cause severe gastrointestinal upset, bone marrow suppression (increasing the risk of infection), and neurological signs. * **Monitoring**: Strict adherence to follow-up appointments for bloodwork (CBCs) is mandatory to ensure your pet's white blood cell counts remain safe. * **Safety at Home**: Because this drug is a known teratogen (can cause birth defects) and is excreted in bodily fluids, pregnant women, nursing mothers, and children should avoid handling the medication or the pet's waste (urine/feces) for several days post-treatment. Wear gloves when cleaning up accidents.
Fluorouracil對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。