依托度酸

用途

• Treatment of pain and inflammation associated with osteoarthritis
• Treatment of pain and inflammation associated with osteoarthritis

給藥方式

可能的副作用

• Vomiting
• Regurgitation
• Diarrhea
• Lethargy
• Hypoproteinemia
• Urticaria
• Behavioral changes
• Inappetence
• Hepatotoxicity (rare)
• Nephrotoxicity (rare)
• Localized pain or tissue reactions at injection site
• Decreased total serum T4
• Keratoconjunctivitis sicca (KCS)

注意事項與禁忌

• Known hypersensitivity to etodolac
• Dogs less than 12 months of age
• Breeding, pregnant, or lactating dogs (safe use not established)
• Cats (highly sensitive to toxicity)
• Use with caution in dogs with preexisting or occult **GI, hepatic, renal, cardiovascular, or hematologic abnormalities** as NSAIDs may exacerbate these conditions. > **Important**: Patients may be more susceptible to renal injury from etodolac if they are dehydrated, on diuretics, or have preexisting renal, hepatic, or cardiovascular dysfunction. Terminate therapy if inappetence, vomiting, fecal abnormalities, or anemia are observed.

藥物相互作用

• ACE Inhibitors (enalapril, benazepril): May reduce antihypertensive effects and increase the risk for renal injury.
• Aspirin: May decrease etodolac plasma levels and increase likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
• Cyclosporine: May increase cyclosporine blood levels and increase the risk for nephrotoxicity.
• Digoxin: May increase serum levels of digoxin. Use with caution in severe cardiac failure.
• Furosemide & other diuretics: May reduce the saluretic and diuretic effects of furosemide.
• Methotrexate: Serious toxicity has occurred with concomitant NSAID use.
• Nephrotoxic agents (amphotericin B, aminoglycosides, cisplatin): Potential for increased risk of nephrotoxicity.
• Phenobarbital: May increase the metabolism of etodolac in dogs.
• Probenecid: May cause a significant increase in serum levels and half-life of etodolac.
• Warfarin: May increase the risk for bleeding.

常見問題