麥角鈣化醇 (維生素D2)
別名: Drisdol, Calciferol Drops
藥物類別: Vitamin D Analog
* **成本與療效**：雖然麥角鈣化醇比其他維生素D藥物（如骨化三醇）便宜，但通常不作為首選，因為它需要較長時間才能發揮作用，且在體內停留的時間更長。 * **終身治療**：使用維生素D產品治療甲狀旁腺問題通常需要終身服藥，並定期回診進行血液檢查。 * **高血鈣風險**：雖然此藥物可以治療低血鈣，但過量會導致血鈣濃度危險地升高。由於藥物儲存在體脂肪中，即使停藥，這種毒性副作用也可能持續數週。 * **注意症狀**：如果您的寵物出現高血鈣症狀，如劇烈口渴、排尿增加、嘔吐或極度疲倦，請立即聯繫您的獸醫師。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Maintenance therapy of parathyroid failure after using parenteral calcium to control hypocalcemic tetany
- Maintenance therapy of parathyroid failure after using parenteral calcium to control hypocalcemic tetany
給藥方式
PO
可能的副作用
- Hypercalcemia
- Hyperphosphatemia
- Nephrocalcinosis
- Soft tissue mineralization
注意事項與禁忌
- Hypercalcemia
- Vitamin D toxicity
- Malabsorption syndrome
- Abnormal sensitivity to the effects of vitamin D
- ### Important Warnings * **Renal Impairment**: Patients with kidney dysfunction may not convert ergocalciferol into the primary active metabolite. Calcitriol or DHT is preferred as they bypass renal activation. * **Hyperphosphatemia**: Use with extreme caution. Elevated calcium and phosphorus simultaneously can lead to severe metastatic soft tissue mineralization (monitor calcium x phosphorus product). * **Monitoring Commitment**: Chronic therapy should not be initiated unless owners are willing to commit to ongoing, rigorous patient monitoring. * **Pregnancy**: Hypervitaminosis D has been implicated in causing teratogenic effects. Weigh potential benefits against risks. * **Nursing**: Large doses of vitamin D are excreted into milk. Consider using milk replacer for offspring of dams receiving therapeutic dosages.
藥物相互作用
- Corticosteroids: Can reduce the effects of vitamin D analogs by decreasing calcium absorption and increasing renal excretion.
- Digoxin: Patients are highly sensitive to the arrhythmogenic effects of hypercalcemia; intensified monitoring is required.
- Verapamil: Patients are sensitive to the effects of hypercalcemia; intensified monitoring is required.
- Mineral Oil: May reduce the amount of orally administered ergocalciferol absorbed from the GI tract.
- Thiazide Diuretics: May cause hypercalcemia when given in conjunction with Vitamin D analogs due to decreased renal calcium excretion.
常見問題
麥角鈣化醇 (維生素D2)用於寵物有什麼用途？
• 成本與療效：雖然麥角鈣化醇比其他維生素D藥物（如骨化三醇）便宜，但通常不作為首選，因為它需要較長時間才能發揮作用，且在體內停留的時間更長。 • 終身治療：使用維生素D產品治療甲狀旁腺問題通常需要終身服藥，並定期回診進行血液檢查。 • 高血鈣風險：雖然此藥物可以治療低血鈣，但過量會導致血鈣濃度危險地升高。由於藥物儲存在體脂肪中，即使停藥，這種毒性副作用也可能持續數週。 • 注意症狀：如果您的寵物出現高血鈣症狀，如劇烈口渴、排尿增加、嘔吐或極度疲倦，請立即聯繫您的獸醫師。
麥角鈣化醇 (維生素D2)對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。