多沙普侖

用途

• Gas anesthesia recovery
• Barbiturate anesthesia recovery
• To initiate or stimulate respirations in neonates after caesarian section or dystocia
• To stimulate respiratory function in neonates
• Primary apnea in asphyxic calves when intubation and mechanical ventilation are not feasible
• Primary apnea in newborn calves
• Halothane, methoxyflurane anesthesia recovery
• Chloral hydrate ± magnesium sulfate anesthesia recovery
• Adjunctive treatment to stimulate respirations in foals with sepsis or hypoxic-ischemic encephalopathy
• Respiratory depression
• Respiratory depression (Rabbits)
• Respiratory depression (Rodents)

給藥方式

可能的副作用

• Hypertension
• Arrhythmias
• Tachycardia
• Seizures (at high doses)
• Hyperventilation leading to respiratory alkalosis
• Increased myocardial oxygen demand
• Reduced cerebral blood flow
• Skeletal muscle hyperactivity

注意事項與禁忌

• Patients receiving mechanical ventilation
• Hypersensitivity to doxapram
• Seizure disorders
• Head trauma or cerebrovascular accidents (CVA)
• Uncompensated heart failure
• Severe hypertension
• Respiratory failure secondary to neuromuscular disorders
• Airway obstruction
• Pulmonary embolism
• Pneumothorax
• Acute asthma
• Dyspnea
• Hypoxia not associated with hypercapnia
• Premature calves or patients with clinical signs of lung immaturity

藥物相互作用

• General Anesthetics (e.g., halothane, enflurane): Doxapram may increase epinephrine release and sensitize the myocardium to catecholamines. Use should be delayed for ~10 minutes after discontinuing these anesthetics.
• Muscle Relaxants: Doxapram may mask the effects of muscle relaxant drugs.
• Sympathomimetic Agents: Additive pressor (blood pressure increasing) effects may occur.

常見問題