達卡巴仁 / 達卡巴肼
別名: DTIC-Dome, Asercit, DTI, Dacarb, Dacarbaziba, Dacatic, Deticene, Detilem, Detimedac, Fauldetic, Ifadac, Oncocarbil, DTIC, Medac, Dacarbazine medac
您的寵物已被處方一種化學治療藥物。請遵守以下指引： * **腸胃不適：** 嘔吐、腹瀉和食慾不振是常見的副作用。您的獸醫可能會開立止吐藥物，讓您在治療前後給予寵物。如果嘔吐或腹瀉嚴重，或排泄物中帶血，請立即聯繫您的獸醫。 * **感染風險：** 此藥物會降低寵物的白血球數量，使其更容易受到感染。請密切注意寵物是否有嗜睡、發燒或精神沉鬱的跡象。 * **出血風險：** 請注意是否有異常出血、瘀傷，或尿液/糞便中帶血的情況，因為此藥物會降低血小板數量。 * **安全預防措施：** 化療藥物具有危險性。在治療後的幾天內，請遵循獸醫的指示安全處理寵物的排泄物（尿液、糞便、嘔吐物）。孕婦、哺乳期婦女及免疫力低下者應避免接觸寵物的排泄物。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Relapsed lymphoma, soft tissue sarcomas, melanoma
- Relapsed Lymphoma (Rescue Protocol)
- Relapsed Lymphoma (Alternative schedule)
給藥方式
可能的副作用
- Severe gastrointestinal toxicity (vomiting, anorexia, diarrhea) - often dose-limiting
- Bone marrow suppression (leukopenia, thrombocytopenia) - nadir occurs several weeks post-treatment
- Severe tissue damage and pain (if extravasated)
- Venous spasm and phlebitis during IV administration
- Alopecia (rare)
- Hepatotoxicity (rare)
- Renal impairment (rare)
- Photosensitivity (rare)
- Severe nausea and vomiting
- Myelosuppression (neutropenia, thrombocytopenia)
- Tissue necrosis if extravasated
- Hepatotoxicity
- Lethargy
注意事項與禁忌
- Cats (due to unknown hepatic metabolism capabilities)
- Patients with known hypersensitivity to the drug
- Pregnancy (teratogenic)
- Pre-existing severe myelosuppression
- Severe hepatic dysfunction
- Pregnancy and lactation
- Known hypersensitivity
- > **WARNING: VESICANT.** Dacarbazine can cause extensive pain and severe tissue damage if extravasated. Dilution and administration by IV infusion is strongly recommended. * Use with extreme caution in patients with preexisting bone marrow depression, hepatic or renal dysfunction, or active infections. * Pretreatment with antiemetics (e.g., ondansetron, dolasetron) is highly recommended due to severe GI toxicity. * Pretreatment with dexamethasone and/or butorphanol may reduce vasospasm, phlebitis, and pain during infusion. * **Human Safety:** Chronic exposure increases mutagenic, teratogenic, and carcinogenic risks. Proper hazardous drug handling precautions are mandatory.
藥物相互作用
- Myelosuppressive drugs (e.g., other antineoplastics, chloramphenicol, flucytosine, colchicine): May cause additive myelosuppression when used concurrently with DTIC.
- Rifampin: May increase the hepatic metabolism of DTIC.
- Phenobarbital: May increase the hepatic metabolism of DTIC.
- Phenytoin: May increase the hepatic metabolism of DTIC.
- Other myelosuppressive agents: Additive bone marrow suppression
常見問題
達卡巴仁 / 達卡巴肼用於寵物有什麼用途？
您的寵物已被處方一種化學治療藥物。請遵守以下指引： * **腸胃不適：** 嘔吐、腹瀉和食慾不振是常見的副作用。您的獸醫可能會開立止吐藥物，讓您在治療前後給予寵物。如果嘔吐或腹瀉嚴重，或排泄物中帶血，請立即聯繫您的獸醫。 * **感染風險：** 此藥物會降低寵物的白血球數量，使其更容易受到感染。請密切注意寵物是否有嗜睡、發燒或精神沉鬱的跡象。 * **出血風險：** 請注意是否有異常出血、瘀傷，或尿液/糞便中帶血的情況，因為此藥物會降低血小板數量。 * **安全預防措施：** 化療藥物具有危險性。在治療後的幾天內，請遵循獸醫的指示安全處理寵物的排泄物（尿液、糞便、嘔吐物）。孕婦、哺乳期婦女及免疫力低下者應避免接觸寵物的排泄物。
達卡巴仁 / 達卡巴肼對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。