Dacarbazine
別名: DTIC-Dome, Asercit, DTI, Dacarb, Dacarbaziba, Dacatic, Deticene, Detilem, Detimedac, Fauldetic, Ifadac, Oncocarbil, DTIC, Medac, Dacarbazine medac
Your pet has been prescribed a chemotherapy medication. Please observe the following guidelines: * **Gastrointestinal Upset:** Vomiting, diarrhea, and loss of appetite are common. Your veterinarian will likely prescribe anti-nausea medications to give before and after treatment. Contact your vet immediately if vomiting or diarrhea is severe or contains blood. * **Infection Risk:** This drug can lower your pet's white blood cell count, making them more susceptible to infections. Watch for signs of lethargy, fever, or depression. * **Bleeding Risk:** Watch for abnormal bleeding, bruising, or blood in the urine or stool, as this drug can lower platelet counts. * **Safety Precautions:** Chemotherapy drugs are hazardous. Follow your veterinarian's instructions regarding the safe handling of your pet's waste (urine, feces, vomit) for a few days following treatment. Pregnant or nursing women, and immunocompromised individuals, should avoid handling the pet's waste.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Relapsed lymphoma, soft tissue sarcomas, melanoma
- Relapsed Lymphoma (Rescue Protocol)
- Relapsed Lymphoma (Alternative schedule)
給藥方式
可能的副作用
- Severe gastrointestinal toxicity (vomiting, anorexia, diarrhea) - often dose-limiting
- Bone marrow suppression (leukopenia, thrombocytopenia) - nadir occurs several weeks post-treatment
- Severe tissue damage and pain (if extravasated)
- Venous spasm and phlebitis during IV administration
- Alopecia (rare)
- Hepatotoxicity (rare)
- Renal impairment (rare)
- Photosensitivity (rare)
- Severe nausea and vomiting
- Myelosuppression (neutropenia, thrombocytopenia)
- Tissue necrosis if extravasated
- Hepatotoxicity
- Lethargy
注意事項與禁忌
- Cats (due to unknown hepatic metabolism capabilities)
- Patients with known hypersensitivity to the drug
- Pregnancy (teratogenic)
- Pre-existing severe myelosuppression
- Severe hepatic dysfunction
- Pregnancy and lactation
- Known hypersensitivity
- > **WARNING: VESICANT.** Dacarbazine can cause extensive pain and severe tissue damage if extravasated. Dilution and administration by IV infusion is strongly recommended. * Use with extreme caution in patients with preexisting bone marrow depression, hepatic or renal dysfunction, or active infections. * Pretreatment with antiemetics (e.g., ondansetron, dolasetron) is highly recommended due to severe GI toxicity. * Pretreatment with dexamethasone and/or butorphanol may reduce vasospasm, phlebitis, and pain during infusion. * **Human Safety:** Chronic exposure increases mutagenic, teratogenic, and carcinogenic risks. Proper hazardous drug handling precautions are mandatory.
藥物相互作用
- Myelosuppressive drugs (e.g., other antineoplastics, chloramphenicol, flucytosine, colchicine): May cause additive myelosuppression when used concurrently with DTIC.
- Rifampin: May increase the hepatic metabolism of DTIC.
- Phenobarbital: May increase the hepatic metabolism of DTIC.
- Phenytoin: May increase the hepatic metabolism of DTIC.
- Other myelosuppressive agents: Additive bone marrow suppression
常見問題
Dacarbazine用於寵物有甚麼用途？
Your pet has been prescribed a chemotherapy medication. Please observe the following guidelines: * **Gastrointestinal Upset:** Vomiting, diarrhea, and loss of appetite are common. Your veterinarian will likely prescribe anti-nausea medications to give before and after treatment. Contact your vet immediately if vomiting or diarrhea is severe or contains blood. * **Infection Risk:** This drug can lower your pet's white blood cell count, making them more susceptible to infections. Watch for signs of lethargy, fever, or depression. * **Bleeding Risk:** Watch for abnormal bleeding, bruising, or blood in the urine or stool, as this drug can lower platelet counts. * **Safety Precautions:** Chemotherapy drugs are hazardous. Follow your veterinarian's instructions regarding the safe handling of your pet's waste (urine, feces, vomit) for a few days following treatment. Pregnant or nursing women, and immunocompromised individuals, should avoid handling the pet's waste.
Dacarbazine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。