頭孢噻呋鈉

用途

• Respiratory disease
• Respiratory disease
• UTI
• Systemic, soft tissue infections
• Sepsis, bacteremia
• Bovine respiratory disease, foot rot
• Respiratory infections (S. zooepidemicus)
• General susceptible infections
• Lyme disease
• General susceptible infections (Foals)
• Strangles
• Intrauterine infusion
• General susceptible infections (Foals)
• Control of early mortality (Day-Old Turkey Poults)

給藥方式

可能的副作用

• Immediate and transient local pain on IM injection
• Discoloration at SC injection sites (may persist >5 days)
• Localized post-injection bacterial infections/abscesses (cattle)
• Hypersensitivity reactions (rashes, fever, eosinophilia, lymphadenopathy, anaphylaxis)
• Acute diarrhea (especially in stressed horses)
• Granulocytopenia
• Thrombocytopenia

注意事項與禁忌

• Patients with a history of hypersensitivity to cephalosporins
• Caution in patients with documented hypersensitivity to other beta-lactam antibiotics (penicillins, cefamycins, carbapenems)
• > **Regulatory Warning:** Strict adherence to withdrawal times is required for food-producing animals. Not to be used in horses intended for human consumption. * **Renal Impairment:** Patients in renal failure may require dosage adjustments due to decreased clearance. * **Cross-Reactivity:** Use with caution in patients allergic to penicillins due to potential cross-reactivity (estimated 1-15% in humans; unknown in veterinary species). * **Laboratory Interference:** May cause false-positive urine glucose (cupric sulfate methods), falsely elevated serum/urine creatinine (Jaffe reaction), false-positive direct Coombs' test, and falsely elevated 17-ketosteroid values in urine. * **GI Flora:** May alter bowel flora, potentially leading to severe diarrhea, particularly in stressed horses.

藥物相互作用

• Aminoglycosides: Potential for additive nephrotoxicity; in vitro synergy exists, but drugs should not be mixed in the same syringe/fluid line.
• Nephrotoxic drugs (e.g., Amphotericin B): Potential for additive nephrotoxicity.
• Probenecid: Competitively blocks the tubular secretion of most cephalosporins, increasing serum levels and serum half-lives.

常見問題