頭孢噻呋鹽酸鹽

用途

• Susceptible urinary tract infections
• Sepsis/bacteraemia
• Bovine respiratory disease and acute bovine interdigital necrobacillosis
• Bovine respiratory disease (BRD) only
• Acute post-partum metritis
• Neonatal salmonellosis
• Subclinical mastitis at time of dry off
• Clinical mastitis in lactating dairy cattle
• Bacterial respiratory disease

給藥方式

可能的副作用

• Pain on IM injection (especially in small animals)
• Hypersensitivity reactions (rashes, fever, eosinophilia, lymphadenopathy, anaphylaxis)
• Gastrointestinal distress / diarrhea
• Granulocytopenia (rare)
• Thrombocytopenia (rare)
• Injection site discoloration

注意事項與禁忌

• Patients with a documented history of hypersensitivity to cephalosporins
• Use with caution in patients hypersensitive to other beta-lactam antibiotics (e.g., penicillins, carbapenems) due to potential cross-reactivity
• > **Warning:** Hypersensitivity reactions can occur. Cross-reactivity with penicillins is possible. * **Tissue Discoloration:** IM or SC injections can cause injection site discoloration, resulting in trim-out of edible tissues at slaughter (persisting up to 11 days in the neck, or >28 days in the rear leg of cattle). * **Withdrawal Times:** Strict adherence to slaughter and milk withdrawal times is legally required and varies significantly by specific product and species. * **Renal Impairment:** Patients in renal failure may require dosage adjustments due to decreased clearance. * **Laboratory Interference:** May cause false-positive urine glucose tests (cupric sulfate method), falsely elevated creatinine (Jaffe reaction), and false-positive direct Coombs' tests.

藥物相互作用

• Aminoglycosides / Nephrotoxic Drugs (e.g., amphotericin B): Potential for additive nephrotoxicity. In vitro studies show synergistic antibacterial activity, but they must NOT be mixed together in the same syringe or fluid line.
• Probenecid: Competitively blocks the tubular secretion of most cephalosporins, thereby increasing serum levels and prolonging serum half-lives.
• Aminoglycosides: Synergistic antibacterial effect, but should not be mixed in the same syringe due to chemical incompatibility.
• Amphotericin B: Increased risk of nephrotoxicity.
• Loop diuretics (e.g., furosemide): Increased risk of nephrotoxicity.

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