頭孢替坦

用途

• Sepsis
• Susceptible infections
• Soft tissue infections
• Bacteremia, sepsis

給藥方式

可能的副作用

• Pain at IM injection site
• Thrombophlebitis (IV administration)
• Hypersensitivity reactions (rash, fever, anaphylaxis)
• Bleeding tendencies (hypoprothrombinemia due to NMTT side chain)
• Gastrointestinal flora alteration (diarrhea, superinfections)
• Rarely: nephrotoxicity, neurotoxicity, neutropenia, thrombocytopenia at high doses

注意事項與禁忌

• Known hypersensitivity to cephamycins or cephalosporins
• Caution in patients with documented hypersensitivity to penicillins or other beta-lactams (cross-reactivity possible)
• Caution in patients with severe renal dysfunction (dose interval adjustment may be required)
• > **Cross-Reactivity:** Use cautiously in patients with known penicillin allergies due to a 1-15% chance of cross-reactivity. > **Renal Impairment:** Elimination half-lives may be significantly prolonged in patients with severely diminished renal function; dosing intervals may need to be extended. > **Laboratory Interference:** May cause false-positive urine glucose tests (cupric sulfate method) and falsely elevated serum/urine creatinine (Jaffe reaction). Can also cause a false-positive direct Coombs' test.

藥物相互作用

• Alcohol: Potential for a disulfiram-like reaction (vomiting, etc.) due to the NMTT side chain.
• Aminoglycosides: Potential additive nephrotoxicity; do not mix together in the same syringe/fluid bag (administer separately). May have synergistic antibacterial activity.
• Nephrotoxic drugs (e.g., Amphotericin B): Potential additive nephrotoxicity.

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