卡馬西平

用途

• For photic head shaking
• As a psychotherapeutic agent

給藥方式

可能的副作用

• Sedation and lethargy
• Ataxia (unsteadiness)
• Gastrointestinal upset (vomiting, anorexia)
• Hepatotoxicity (elevated liver enzymes)
• Blood dyscrasias (rare but possible bone marrow suppression)

注意事項與禁忌

• Patients receiving MAO Inhibitors (e.g., selegiline) within the past 14 days
• Patients with a history of bone marrow depression
• Known hypersensitivity to carbamazepine or tricyclic antidepressants
• Use with extreme caution due to extensive drug interactions (it is a potent inducer of hepatic enzymes). In dogs, it rapidly induces its own metabolism (autoinduction), making long-term therapeutic dosing difficult. May interfere with thyroid function tests (decreased values) and some pregnancy tests, though veterinary significance is unclear.

藥物相互作用

• Azole Antifungals (e.g., Ketoconazole, Itraconazole): May increase plasma levels or effects of carbamazepine
• Calcium Channel Blockers (e.g., Diltiazem, Verapamil): May increase plasma levels or effects of carbamazepine; Carbamazepine may also decrease their effects
• Cimetidine: May increase plasma levels or effects of carbamazepine
• Danazol: May increase plasma levels or effects of carbamazepine
• Grapefruit Juice: May increase plasma levels or effects of carbamazepine
• Isoniazid: May increase plasma levels or effects of carbamazepine; Carbamazepine may also increase effects of Isoniazid
• Macrolides (e.g., Erythromycin, Clarithromycin): May increase plasma levels or effects of carbamazepine
• MAO Inhibitors (e.g., Selegiline): Contraindicated; discontinue MAOI at least 14 days prior to carbamazepine
• Niacin: May increase plasma levels or effects of carbamazepine
• SSRI Antidepressants (e.g., Fluoxetine): May increase plasma levels or effects of carbamazepine

常見問題