博來黴素

用途

• Antineoplastic therapy (General guide)
• Antineoplastic therapy (General guide)

給藥方式

可能的副作用

• Fever
• Anorexia
• Vomiting
• Allergic reactions (including anaphylaxis)
• Alopecia
• Skin rashes
• Stomatitis
• Pneumonitis
• Pulmonary fibrosis (potentially fatal)
• Thrombocytopenia (mild)
• Leukopenia (mild)
• Decreased hemoglobin
• Renal toxicity
• Hepatotoxicity

注意事項與禁忌

• Prior hypersensitivity reactions to the drug
• Preexisting pulmonary disease
• Adverse pulmonary effects from prior therapy
• Pregnancy (unless owners accept the associated teratogenic risks)
• Bleomycin is a toxic drug with a low therapeutic index; it should only be used by personnel equipped to actively monitor patients and handle complications. Use very cautiously in patients with significant renal impairment (dosage reduction may be necessary). It is teratogenic (FDA Category D). To reduce the likelihood of fatal pulmonary toxicity, a total maximum cumulative dosage of 125-200 mg/m2 should not be exceeded.

藥物相互作用

• General Anesthetics: Bleomycin sensitizes lung tissue to oxygen. Use of general anesthetics can cause rapid deterioration of pulmonary function and post-operative pulmonary fibrosis, even at safe inspired oxygen concentrations.
• Other Chemotherapy Agents or Radiation Therapy: Prior or concomitant use can lead to increased hematologic, mucosal, and pulmonary toxicities.

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