Bleomycin
別名: Blenoxane, Blenamax, Bleocin, Bileco, Blanoxan
> **Critical Warning:** Bleomycin can cause severe and potentially irreversible lung damage. * **Breathing Changes:** Monitor your pet's breathing closely. Contact your veterinarian **immediately** if you notice coughing, wheezing, shortness of breath, or increased effort to breathe. * **Skin and Mouth Sores:** Watch for hair loss, skin rashes, or sores in the mouth (stomatitis). Offer soft foods if your pet's mouth appears sensitive. * **General Signs:** Mild fever, loss of appetite, and vomiting can occur shortly after administration. * **Anesthesia Risk:** If your pet ever needs surgery or anesthesia in the future, you **must** inform the veterinary team that they have received bleomycin. This drug makes the lungs highly sensitive to oxygen therapy, which requires special anesthetic protocols.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Antineoplastic therapy (General guide)
- Antineoplastic therapy (General guide)
給藥方式
可能的副作用
- Fever
- Anorexia
- Vomiting
- Allergic reactions (including anaphylaxis)
- Alopecia
- Skin rashes
- Stomatitis
- Pneumonitis
- Pulmonary fibrosis (potentially fatal)
- Thrombocytopenia (mild)
- Leukopenia (mild)
- Decreased hemoglobin
- Renal toxicity
- Hepatotoxicity
注意事項與禁忌
- Prior hypersensitivity reactions to the drug
- Preexisting pulmonary disease
- Adverse pulmonary effects from prior therapy
- Pregnancy (unless owners accept the associated teratogenic risks)
- Bleomycin is a toxic drug with a low therapeutic index; it should only be used by personnel equipped to actively monitor patients and handle complications. Use very cautiously in patients with significant renal impairment (dosage reduction may be necessary). It is teratogenic (FDA Category D). To reduce the likelihood of fatal pulmonary toxicity, a total maximum cumulative dosage of 125-200 mg/m2 should not be exceeded.
藥物相互作用
- General Anesthetics: Bleomycin sensitizes lung tissue to oxygen. Use of general anesthetics can cause rapid deterioration of pulmonary function and post-operative pulmonary fibrosis, even at safe inspired oxygen concentrations.
- Other Chemotherapy Agents or Radiation Therapy: Prior or concomitant use can lead to increased hematologic, mucosal, and pulmonary toxicities.
常見問題
Bleomycin用於寵物有甚麼用途？
> **Critical Warning:** Bleomycin can cause severe and potentially irreversible lung damage. * **Breathing Changes:** Monitor your pet's breathing closely. Contact your veterinarian **immediately** if you notice coughing, wheezing, shortness of breath, or increased effort to breathe. * **Skin and Mouth Sores:** Watch for hair loss, skin rashes, or sores in the mouth (stomatitis). Offer soft foods if your pet's mouth appears sensitive. * **General Signs:** Mild fever, loss of appetite, and vomiting can occur shortly after administration. * **Anesthesia Risk:** If your pet ever needs surgery or anesthesia in the future, you **must** inform the veterinary team that they have received bleomycin. This drug makes the lungs highly sensitive to oxygen therapy, which requires special anesthetic protocols.
Bleomycin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。