阿替美唑
別名: Antisedan, Revertidine, Alzane, Atipam, Revertor, Sedastop, Tipafar
藥物類別: Alpha-2 Adrenergic Antagonist
阿替美唑是一種逆轉劑，用於在鎮靜或麻醉後喚醒您的寵物。本藥物僅應由獸醫專業人員給藥。 **在家中需要注意的事項：** * 偶爾，寵物在接受此藥物後可能會出現嘔吐、腹瀉、流口水（唾液分泌過多）、過度興奮或發抖的情況。 * 由於該藥物會迅速消除鎮靜和止痛效果，如果您的寵物接受了會引起疼痛的處置，牠們可能會顯得焦慮或不適。請確保按照指示給予任何處方的止痛藥。 * 如果任何副作用很嚴重，或者您的寵物在離開診所後顯得過度焦躁或再次陷入昏睡，請立即聯繫您的獸醫。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- For reversal of alpha2-adrenergic agonists in caprine species
- Small ruminants
- For reversal of alpha2-adrenergic agonists in ovine species
- Small ruminants
- For reversal of medetomidine
- For reversal of medetomidine
- For reversal of dexmedetomidine
- For treatment of amitraz toxicity
- Reversal of medetomidine or dexmedetomidine
- Amitraz toxicity
- As a reversal agent for alpha2-adrenergic agonists (e.g., xylazine, detomidine, etc.)
- For reversal of medetomidine as part of a medetomidine/butorphanol or buprenorphine/ketamine/carprofen or meloxicam anesthesia/analgesia injectable combination
- For reversal of dexmedetomidine
- Reversal of medetomidine or dexmedetomidine
- For reversal of alpha2-adrenergic agonists in bovine
- For medetomidine reversal in Rabbits
- To reverse xylazine or medetomidine in Mice, Rats, Gerbils, Hamsters, Guinea pigs
- Reversal of all dosages ketamine/medetomidine combination
給藥方式
IMIVSCIP
可能的副作用
- Vomiting
- Diarrhea
- Hypersalivation
- Tremors
- Brief excitation or apprehensiveness
- Aggression upon rapid waking
- Profound hypotension (if given IV in reptiles)
- Loss of analgesia
注意事項與禁忌
- Reptiles (Intravenous administration is contraindicated due to profound hypotension)
- > **Pregnancy/Lactation:** Not recommended in pregnant or lactating animals, or animals intended for breeding due to lack of safety data. * **Rapid Emergence:** Because reversal can occur rapidly, care should be exercised as animals emerging from sedation and analgesia may exhibit apprehensive or aggressive behaviors. Protect animals from falling or self-harm. * **Loss of Analgesia:** Additional analgesia (e.g., butorphanol, buprenorphine) should be considered, particularly after painful procedures. * **Relapse of Sedation:** When used as an antidote for alpha-2 agonist toxicity (e.g., amitraz), atipamezole's effects may subside before non-toxic levels of the offending agent are reached; repeat dosing may be necessary. * **Geriatric/Debilitated Patients:** Caution should be used in administration of anesthetic agents to elderly or debilitated animals. * **Reptiles:** Do NOT give IV to reptiles as profound hypotension can occur.
藥物相互作用
- Alpha-1 adrenergic blockers (e.g., prazosin): Atipamezole can partially block alpha-1 receptors and reduce the effects of prazosin.
- Alpha-2 adrenergic agonists (e.g., detomidine, clonidine, brimonidine, xylazine, amitraz): Atipamezole can reduce the effects (toxic or therapeutic) of these agents.
- Medetomidine: Reverses sedative, analgesic, and cardiovascular effects (intended therapeutic interaction)
- Dexmedetomidine: Reverses sedative, analgesic, and cardiovascular effects (intended therapeutic interaction)
- Ketamine: If atipamezole is given less than 30 minutes after a medetomidine/ketamine combination in cats, it can cause severe CNS excitation during recovery.
- Other alpha-2 antagonists: Additive antagonistic effects
- Hypotensive agents: May exacerbate transient hypotension
常見問題
阿替美唑用於寵物有什麼用途？
阿替美唑是一種逆轉劑，用於在鎮靜或麻醉後喚醒您的寵物。本藥物僅應由獸醫專業人員給藥。 在家中需要注意的事項： • 偶爾，寵物在接受此藥物後可能會出現嘔吐、腹瀉、流口水（唾液分泌過多）、過度興奮或發抖的情況。 • 由於該藥物會迅速消除鎮靜和止痛效果，如果您的寵物接受了會引起疼痛的處置，牠們可能會顯得焦慮或不適。請確保按照指示給予任何處方的止痛藥。 • 如果任何副作用很嚴重，或者您的寵物在離開診所後顯得過度焦躁或再次陷入昏睡，請立即聯繫您的獸醫。
阿替美唑對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。