Atipamezole
別名: Antisedan, Revertidine, Alzane, Atipam, Revertor, Sedastop, Tipafar
Atipamezole is a reversal agent used to wake your pet up after sedation or anesthesia. It should be administered by veterinary professionals only. **What to watch for at home:** * Occasionally, pets may experience vomiting, diarrhea, drooling (hypersalivation), excitation, or tremors after receiving this medication. * Because the medication rapidly removes pain relief along with sedation, your pet may seem anxious or uncomfortable if they had a painful procedure. Ensure you give any prescribed pain medications as directed. * If any side effects are severe, or if your pet seems excessively agitated or re-sedated after leaving the clinic, contact your veterinarian immediately.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For reversal of alpha2-adrenergic agonists in caprine species
- Small ruminants
- For reversal of alpha2-adrenergic agonists in ovine species
- Small ruminants
- For reversal of medetomidine
- For reversal of medetomidine
- For reversal of dexmedetomidine
- For treatment of amitraz toxicity
- Reversal of medetomidine or dexmedetomidine
- Amitraz toxicity
- As a reversal agent for alpha2-adrenergic agonists (e.g., xylazine, detomidine, etc.)
- For reversal of medetomidine as part of a medetomidine/butorphanol or buprenorphine/ketamine/carprofen or meloxicam anesthesia/analgesia injectable combination
給藥方式
可能的副作用
- Vomiting
- Diarrhea
- Hypersalivation
- Tremors
- Brief excitation or apprehensiveness
- Aggression upon rapid waking
- Profound hypotension (if given IV in reptiles)
- Loss of analgesia
注意事項與禁忌
- Reptiles (Intravenous administration is contraindicated due to profound hypotension)
- > **Pregnancy/Lactation:** Not recommended in pregnant or lactating animals, or animals intended for breeding due to lack of safety data. * **Rapid Emergence:** Because reversal can occur rapidly, care should be exercised as animals emerging from sedation and analgesia may exhibit apprehensive or aggressive behaviors. Protect animals from falling or self-harm. * **Loss of Analgesia:** Additional analgesia (e.g., butorphanol, buprenorphine) should be considered, particularly after painful procedures. * **Relapse of Sedation:** When used as an antidote for alpha-2 agonist toxicity (e.g., amitraz), atipamezole's effects may subside before non-toxic levels of the offending agent are reached; repeat dosing may be necessary. * **Geriatric/Debilitated Patients:** Caution should be used in administration of anesthetic agents to elderly or debilitated animals. * **Reptiles:** Do NOT give IV to reptiles as profound hypotension can occur.
藥物相互作用
- Alpha-1 adrenergic blockers (e.g., prazosin): Atipamezole can partially block alpha-1 receptors and reduce the effects of prazosin.
- Alpha-2 adrenergic agonists (e.g., detomidine, clonidine, brimonidine, xylazine, amitraz): Atipamezole can reduce the effects (toxic or therapeutic) of these agents.
- Medetomidine: Reverses sedative, analgesic, and cardiovascular effects (intended therapeutic interaction)
- Dexmedetomidine: Reverses sedative, analgesic, and cardiovascular effects (intended therapeutic interaction)
- Ketamine: If atipamezole is given less than 30 minutes after a medetomidine/ketamine combination in cats, it can cause severe CNS excitation during recovery.
- Other alpha-2 antagonists: Additive antagonistic effects
- Hypotensive agents: May exacerbate transient hypotension
常見問題
Atipamezole用於寵物有甚麼用途？
Atipamezole is a reversal agent used to wake your pet up after sedation or anesthesia. It should be administered by veterinary professionals only. **What to watch for at home:** * Occasionally, pets may experience vomiting, diarrhea, drooling (hypersalivation), excitation, or tremors after receiving this medication. * Because the medication rapidly removes pain relief along with sedation, your pet may seem anxious or uncomfortable if they had a painful procedure. Ensure you give any prescribed pain medications as directed. * If any side effects are severe, or if your pet seems excessively agitated or re-sedated after leaving the clinic, contact your veterinarian immediately.
Atipamezole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。