阿維A

用途

• Actinic keratosis/solar-induced squamous cell carcinoma; or Bowen's Disease
• Bowen's Disease
• Dermatologic conditions where retinoids may be useful
• Dermatologic conditions where retinoids may be useful
• Sebaceous adenitis

給藥方式

可能的副作用

• Anorexia
• Vomiting
• Diarrhea
• Cracking of foot pads
• Pruritus
• Ventral abdominal erythema
• Polydipsia
• Lassitude
• Joint pain/stiffness
• Eyelid abnormalities
• Keratoconjunctivitis sicca (KCS)
• Swollen tongue
• Behavioral changes
• Weight loss (especially in cats)

注意事項與禁忌

• Pregnancy (absolute contraindication)
• Cardiovascular disease
• Hypertriglyceridemia
• Known sensitivity to acitretin or other retinoids
• > **TERATOGEN WARNING**: Acitretin is a known teratogen (FDA Category X). It should not be handled by pregnant women nor used in a household where women are pregnant or planning to become pregnant. * Use with caution in patients with renal or hepatic failure. * May cause significant alterations in lipid profiles (hypertriglyceridemia, hypercholesterolemia) and liver enzymes.

藥物相互作用

• Alcohol: Acitretin can form etretinate in the presence of alcohol; etretinate is a teratogen with an extremely long terminal half-life that can persist in adipose tissue for years.
• Hepatotoxic drugs (e.g., methotrexate, ketoconazole, sulfonamides, fluconazole, macrolides): May increase the potential for hepatotoxicity.
• Other retinoids (isotretinoin, tretinoin, vitamin A): May cause additive toxic effects.
• Tetracyclines: May increase the potential for the occurrence of pseudotumor cerebri (cerebral edema and increased CSF pressure).

常見問題