Acitretin
別名: Soriatane
> **CRITICAL SAFETY WARNING**: Acitretin causes severe birth defects. **Pregnant women, or women planning to become pregnant, MUST NOT handle this medication.** Veterinarians and clients must strictly manage the risk of exposure. * **Administration**: Give this medication consistently with food to increase its absorption and effectiveness. * **Side Effects**: Monitor your pet for signs of "dry eye" (squinting, thick eye discharge), dry or cracking footpads, vomiting, or loss of appetite. * **Cats**: If your cat stops eating or loses weight, contact your veterinarian immediately. The dosing schedule may need to be adjusted (e.g., given every other day). * **Cost**: Be aware that long-term therapy with this medication can be quite expensive.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Actinic keratosis/solar-induced squamous cell carcinoma; or Bowen's Disease
- Bowen's Disease
- Dermatologic conditions where retinoids may be useful
- Dermatologic conditions where retinoids may be useful
- Sebaceous adenitis
給藥方式
可能的副作用
- Anorexia
- Vomiting
- Diarrhea
- Cracking of foot pads
- Pruritus
- Ventral abdominal erythema
- Polydipsia
- Lassitude
- Joint pain/stiffness
- Eyelid abnormalities
- Keratoconjunctivitis sicca (KCS)
- Swollen tongue
- Behavioral changes
- Weight loss (especially in cats)
注意事項與禁忌
- Pregnancy (absolute contraindication)
- Cardiovascular disease
- Hypertriglyceridemia
- Known sensitivity to acitretin or other retinoids
- > **TERATOGEN WARNING**: Acitretin is a known teratogen (FDA Category X). It should not be handled by pregnant women nor used in a household where women are pregnant or planning to become pregnant. * Use with caution in patients with renal or hepatic failure. * May cause significant alterations in lipid profiles (hypertriglyceridemia, hypercholesterolemia) and liver enzymes.
藥物相互作用
- Alcohol: Acitretin can form etretinate in the presence of alcohol; etretinate is a teratogen with an extremely long terminal half-life that can persist in adipose tissue for years.
- Hepatotoxic drugs (e.g., methotrexate, ketoconazole, sulfonamides, fluconazole, macrolides): May increase the potential for hepatotoxicity.
- Other retinoids (isotretinoin, tretinoin, vitamin A): May cause additive toxic effects.
- Tetracyclines: May increase the potential for the occurrence of pseudotumor cerebri (cerebral edema and increased CSF pressure).
常見問題
Acitretin用於寵物有甚麼用途？
> **CRITICAL SAFETY WARNING**: Acitretin causes severe birth defects. **Pregnant women, or women planning to become pregnant, MUST NOT handle this medication.** Veterinarians and clients must strictly manage the risk of exposure. * **Administration**: Give this medication consistently with food to increase its absorption and effectiveness. * **Side Effects**: Monitor your pet for signs of "dry eye" (squinting, thick eye discharge), dry or cracking footpads, vomiting, or loss of appetite. * **Cats**: If your cat stops eating or loses weight, contact your veterinarian immediately. The dosing schedule may need to be adjusted (e.g., given every other day). * **Cost**: Be aware that long-term therapy with this medication can be quite expensive.
Acitretin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。