乙醯胺酚 / 撲熱息痛

用途

• Analgesic (Rabbits)
• Analgesic (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas)
• Analgesic
• Analgesic
• Analgesic
• Treatment of degenerative myelopathy (in German Shepherds)

給藥方式

可能的副作用

• Methemoglobinemia (especially in cats and dogs at high doses)
• Hepatotoxicity (liver necrosis)
• Renal effects
• Gastrointestinal disturbances
• Facial and paw swelling (edema)
• Keratoconjunctivitis sicca (KCS)
• Cyanosis
• Hypothermia

注意事項與禁忌

• Cats (at any dosage)
• Ferrets
• Sugar Gliders
• Hedgehogs
• **WARNINGS:** * **ABSOLUTELY CONTRAINDICATED IN CATS AND FERRETS.** Severe methemoglobinemia, hematuria, icterus, and death can occur. * Dogs do not metabolize acetaminophen as well as humans; use judiciously to avoid methemoglobinemia and hepatotoxicity. * Not recommended during the immediate post-operative phase (first 24 hours) in dogs due to increased risk of hepatotoxicity. * Use cautiously in pregnant animals (FDA Category B in humans, Papich Class C in veterinary).

藥物相互作用

• Other Analgesics: Chronic use with acetaminophen may lead to renal pathologies
• Barbiturates: Increased conversion of acetaminophen to hepatotoxic metabolites; potentially increased risk for hepatotoxicity
• Doxorubicin: May deplete hepatic glutathione, thereby leading to increased hepatic toxicity
• Halothane: Not recommended for postoperative analgesia in animals that received halothane anesthesia
• Isoniazid: Possible increased risk of hepatotoxicity
• Phenothiazines: Possible increased risk for hypothermia
• Propylene Glycol: May increase the severity of acetaminophen-induced methemoglobinemia or Heinz body formation
• Warfarin: Large doses may potentiate anticoagulant effects

常見問題