Voriconazole
別名: Vfend
**Voriconazole** is an advanced antifungal medication used for severe or resistant fungal infections. * **Investigational Use**: This drug is relatively new in veterinary medicine, and its use is often considered investigational. It is also quite expensive. * **Administration**: Give the medication at least one hour before or one hour after feeding to ensure proper absorption. * **Adverse Effects to Watch For**: Because experience with this drug in pets is limited, monitor your pet closely. **Contact your veterinarian immediately** if you notice: * Itching or skin rashes * Yellowing of the whites of the eyes or gums (jaundice) * Reduced appetite or weight loss * Difficulty walking, stumbling, or weakness (especially in the hind legs) * Vision problems or dilated pupils * **Cats**: Cats are particularly sensitive to this medication. Watch them extremely closely for any changes in behavior, appetite, or mobility.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Orbital aspergillosis
- Aspergillosis
- General / Pharmacokinetic study
- Avian aspergillosis
- Coccidioidomycosis
給藥方式
可能的副作用
- Dogs: Liver enlargement, significant increase in cytochrome P450 hepatic enzymes
- Cats: Azotemia, inappetence, lethargy, weight loss, cutaneous drug reactions, ataxia, hind limb paresis/paraplegia, visual signs (mydriasis, decreased PLR), arrhythmias, hypokalemia
- Humans: Visual disturbances (blurring, spots, wavy lines), rashes, GI effects (nausea, vomiting, diarrhea), hepatotoxicity, hypertension/hypotension, tachycardia, peripheral edema, hypokalemia, hypomagnesemia
- Rare (Humans): Eye hemorrhage, anemia, leukopenia, thrombocytopenia, pancytopenia, QT prolongation, nephrotoxicity
注意事項與禁忌
- Hypersensitivity to voriconazole or other azole antifungals
- Concurrent use with barbiturates, carbamazepine, cisapride, pimozide, quinidine, rifampin, or rifabutin
- Caution in patients with hepatic dysfunction
- Caution in patients with proarrhythmic conditions
- Caution with the IV formulation in patients with decreased renal function (due to accumulation of the SBECD vehicle)
- > **Feline Warning**: Cats are highly susceptible to severe neurologic and systemic adverse effects. Use only as a last resort. * **Hepatic Effects**: Can cause liver enlargement and enzyme induction (in dogs). Use with caution in patients with pre-existing hepatic dysfunction. * **Renal Impairment**: The IV formulation contains sulfobutyl ether beta-cyclodextrin sodium (SBECD), which can accumulate in patients with reduced renal function. * **Pregnancy**: Teratogenic in rats and embryotoxic in rabbits (FDA Category D). Weigh risks vs. benefits in pregnant animals. * **Cardiac**: Use with caution in patients with proarrhythmic conditions.
藥物相互作用
- Antidiabetic agents (sulfonylureas): May increase serum concentrations of these drugs and increase risk for hypoglycemia
- Barbiturates (phenobarbital): Decreased voriconazole concentrations; concurrent use is contraindicated
- Benzodiazepines: May increase benzodiazepine concentrations
- Calcium-channel blockers (amlodipine, diltiazem, verapamil): May increase serum concentrations; dosage adjustment may be required
- Carbamazepine: Decreased voriconazole concentrations; concurrent use is contraindicated
- Cisapride: Potential for serious cardiac arrhythmias; concurrent use is contraindicated
- Corticosteroids (prednisolone): Potentially increased AUC for prednisolone
- Immunosuppressive agents (cyclosporine, tacrolimus): Increased concentrations; decrease cyclosporine dosage by 50% and tacrolimus dosage by 33% when starting voriconazole
- Methadone: May increase plasma concentrations of R-methadone; monitor for toxicity
- Phenytoin: Can decrease voriconazole concentrations and voriconazole can increase phenytoin concentrations
常見問題
Voriconazole用於寵物有甚麼用途？
**Voriconazole** is an advanced antifungal medication used for severe or resistant fungal infections. * **Investigational Use**: This drug is relatively new in veterinary medicine, and its use is often considered investigational. It is also quite expensive. * **Administration**: Give the medication at least one hour before or one hour after feeding to ensure proper absorption. * **Adverse Effects to Watch For**: Because experience with this drug in pets is limited, monitor your pet closely. **Contact your veterinarian immediately** if you notice: * Itching or skin rashes * Yellowing of the whites of the eyes or gums (jaundice) * Reduced appetite or weight loss * Difficulty walking, stumbling, or weakness (especially in the hind legs) * Vision problems or dilated pupils * **Cats**: Cats are particularly sensitive to this medication. Watch them extremely closely for any changes in behavior, appetite, or mobility.
Voriconazole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。