Triamterene
別名: Dyrenium, Dytac, Dyazide, Maxzide, Triteren
* **Administration**: Give this medication with food to help prevent stomach upset. * **Urine Color**: Your pet's urine may develop a **bluish hue** while taking this medication; this is a normal and harmless effect. * **Monitoring**: Because this medication has not been used extensively in dogs or cats, closely observe your pet and report any unusual effects (such as severe lethargy, weakness, or vomiting) to your veterinarian immediately. * **Dietary Restrictions**: Do not give your pet potassium supplements or high-potassium foods/treats unless specifically directed by your veterinarian.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of recurrent heart failure associated with chronic mitral valve insufficiency
- As a diuretic for adjunctive treatment of CHF
給藥方式
可能的副作用
- Hyperkalemia (most significant risk)
- Gastrointestinal upset
- Hyponatremia
- Headache or dizziness (reported in humans)
- Increased sensitivity to sunlight
- Hypersensitivity reactions (rare)
- Nephrolithiasis (rare)
- Blood dyscrasias such as agranulocytosis, thrombocytopenia, or megaloblastosis (rare)
注意事項與禁忌
- Anuria
- Severe or progressive renal disease
- Severe hepatic disease
- Hypersensitivity to triamterene
- Preexisting hyperkalemia or history of triamterene-induced hyperkalemia
- Concurrent therapy with another potassium-sparing agent (e.g., spironolactone, amiloride)
- Concurrent potassium supplementation
- > **Warning**: Hyperkalemia is a definite possibility. Monitoring of electrolytes and renal function is strictly necessary. * **Renal Function**: May slightly reduce GFR (reversible upon discontinuation). Use with caution in patients with compromised renal blood flow. * **Pregnancy**: Crosses the placental barrier. Animal studies (rats) at 6-20X human dose showed no adverse fetal effects, but adequate studies are lacking. Weigh potential benefits against risks. * **Lactation**: Distributed into milk. Safety during nursing cannot be assured.
藥物相互作用
- ACE Inhibitors (e.g., enalapril, benazepril): Increased risks for hyperkalemia.
- Antidiabetic Agents (insulin, oral hypoglycemics): Triamterene may increase blood glucose levels.
- Antihypertensive Agents: Possible potentiation of hypotensive effects.
- Diuretics, Potassium-Sparing (spironolactone, amiloride): Increased risk of hyperkalemia; concurrent use is contraindicated.
- Lithium: Triamterene may reduce lithium clearance, increasing the risk of lithium toxicity.
- NSAIDs (especially indomethacin): May increase the risks of nephrotoxicity when used concurrently.
- Potassium Supplements or High Potassium Foods: Increased risk for hyperkalemia.
- Quinidine: Laboratory interaction: Triamterene may interfere with the fluorescent assay of quinidine.
常見問題
Triamterene用於寵物有甚麼用途？
* **Administration**: Give this medication with food to help prevent stomach upset. * **Urine Color**: Your pet's urine may develop a **bluish hue** while taking this medication; this is a normal and harmless effect. * **Monitoring**: Because this medication has not been used extensively in dogs or cats, closely observe your pet and report any unusual effects (such as severe lethargy, weakness, or vomiting) to your veterinarian immediately. * **Dietary Restrictions**: Do not give your pet potassium supplements or high-potassium foods/treats unless specifically directed by your veterinarian.
Triamterene對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。