Trazodone
別名: Desyrel, Oleptro, Molipaxin
- **Administration**: Preferably give with food to minimize gastrointestinal upset (like vomiting or gagging). - **Timing**: For situational anxiety (e.g., vet visits, fireworks), administer **1 to 2 hours before** the anticipated stressful event. - **Observation**: Monitor your pet for excessive sedation, lethargy, or uncoordinated walking (ataxia). - **Paradoxical Effects**: Rarely, pets may exhibit increased excitement, anxiety, or changes in appetite. - **Important Warning**: Do not combine with other medications or supplements (especially tick collars containing amitraz) without consulting your veterinarian, as this can lead to a rare but serious condition called **serotonin syndrome**. - **Communication**: Report any unforeseen adverse effects to your veterinarian, as trazodone is still being studied for extensive use in dogs.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of anxiety-related disorders (Daily medication only)
- Adjunctive treatment of anxiety-related disorders (As needed only)
- Adjunctive treatment of anxiety-related disorders (Daily medication and as needed)
- Adjunctive treatment of anxiety-related disorders
- Adjunctive treatment of anxiety-related disorders
- Adjunctive treatment of anxiety-related disorders (Situational)
給藥方式
可能的副作用
- Sedation
- Lethargy
- Ataxia
- Cardiac conduction disturbances
- Increased anxiety (paradoxical)
- Aggression (paradoxical)
- Vomiting/gagging
- Increased excitement
- Increased appetite
- Colitis
- Serotonin syndrome (rare, usually with concurrent serotonergic drugs)
- Vomiting
- Excitability
- Dry mouth
注意事項與禁忌
- Hypersensitivity to trazodone
- Concurrent use of MAO inhibitors (e.g., amitraz, selegiline)
- Glaucoma
- History of seizures
- Urinary retention
- Severe liver disease
- > **Cardiac & Organ Impairment**: Use with caution in patients with severe cardiac disease or hepatic or renal impairment. > **Pregnancy**: FDA Category C. Animal studies show adverse effects at very high doses (15-50X). Weigh potential risks versus benefits in pregnant or nursing animals. > **Serotonin Syndrome**: Risk increases significantly when combined with other serotonergic drugs (e.g., SSRIs, MAOIs, TCAs).
藥物相互作用
- Antihypertensive drugs: May increase reductions in blood pressure and cause hypotension
- Aspirin: Increase risk for GI bleeding; monitor
- Azole antifungals (e.g., ketoconazole, fluconazole): May increase trazodone blood levels
- CNS depressants: Use with trazodone may cause additive CNS depressant effects
- Digoxin: Trazodone may increase digoxin levels
- Macrolide antibiotics (e.g., erythromycin, clarithromycin): May increase trazodone blood levels
- Metoclopramide: Increased risk for serotonin syndrome
- NSAIDs: Increased risk for GI bleeding; monitor
- Phenothiazines: May increase trazodone blood levels; cause additive CNS effects
- SSRI antidepressants (e.g., fluoxetine): Increased risk for serotonin syndrome. Commonly used together, but monitor closely.
- Monoamine oxidase inhibitors (MAOIs): Contraindicated; high risk of serotonin syndrome
常見問題
Trazodone用於寵物有甚麼用途？
- **Administration**: Preferably give with food to minimize gastrointestinal upset (like vomiting or gagging). - **Timing**: For situational anxiety (e.g., vet visits, fireworks), administer **1 to 2 hours before** the anticipated stressful event. - **Observation**: Monitor your pet for excessive sedation, lethargy, or uncoordinated walking (ataxia). - **Paradoxical Effects**: Rarely, pets may exhibit increased excitement, anxiety, or changes in appetite. - **Important Warning**: Do not combine with other medications or supplements (especially tick collars containing amitraz) without consulting your veterinarian, as this can lead to a rare but serious condition called **serotonin syndrome**. - **Communication**: Report any unforeseen adverse effects to your veterinarian, as trazodone is still being studied for extensive use in dogs.
Trazodone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。