Streptozocin
別名: Zanosar
* **Purpose**: Your dog has been prescribed streptozocin to treat an **insulinoma** (a tumor of the pancreas that causes dangerously low blood sugar). * **Hospitalization Required**: Because this drug can be very hard on the kidneys, your dog will need to stay in the hospital to receive continuous IV fluids before, during, and after the treatment to flush the kidneys and protect them from damage. * **Side Effects**: Nausea and vomiting are very common. Your veterinarian will administer strong anti-nausea medications to keep your dog as comfortable as possible. * **Experimental Nature**: This is considered an 'investigational' or off-label treatment in veterinary medicine. Strict follow-up monitoring of blood sugar, kidney values, and blood counts is absolutely essential.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Recurrent insulinoma after surgery (investigational)
- Pancreatic islet cell tumors
給藥方式
可能的副作用
- Serious, permanent renal toxicity
- Severe and protracted vomiting and nausea
- Mild myelosuppression
- Elevated liver enzymes
- Severe tissue necrosis if extravasated (vesicant)
注意事項與禁忌
- Patients without a confirmed histologic diagnosis of insulinoma
- Patients with completely resectable tumors
- Pregnancy (unless benefits outweigh risks; FDA Category C)
- > **CRITICAL WARNING**: Streptozocin is highly **nephrotoxic**. Aggressive IV saline diuresis is absolutely mandatory before, during, and after administration to prevent permanent renal failure. * Must be used with extreme caution in patients with decreased renal, bone marrow, or hepatic function. * **Vesicant**: Severe tissue necrosis will occur if the drug extravasates outside the vein. Ensure a perfectly placed, patent IV catheter. * **Nursing Safety**: It is unknown if it is excreted in milk. Consider using milk replacer due to the potential for serious adverse reactions in nursing offspring.
藥物相互作用
- Doxorubicin: Streptozocin may prolong the half-life of doxorubicin; dosage adjustment may be required.
- Myelosuppressive drugs (e.g., carmustine): Additive or synergistic myelosuppression may occur.
- Nephrotoxic drugs (aminoglycosides, amphotericin B, cisplatin): May cause additive nephrotoxicity when used concurrently.
- Niacinamide (nicotinamide): Can block the diabetogenic effects of streptozocin without altering its antineoplastic activity; this may be beneficial or detrimental depending on the clinical goal.
常見問題
Streptozocin用於寵物有甚麼用途？
* **Purpose**: Your dog has been prescribed streptozocin to treat an **insulinoma** (a tumor of the pancreas that causes dangerously low blood sugar). * **Hospitalization Required**: Because this drug can be very hard on the kidneys, your dog will need to stay in the hospital to receive continuous IV fluids before, during, and after the treatment to flush the kidneys and protect them from damage. * **Side Effects**: Nausea and vomiting are very common. Your veterinarian will administer strong anti-nausea medications to keep your dog as comfortable as possible. * **Experimental Nature**: This is considered an 'investigational' or off-label treatment in veterinary medicine. Strict follow-up monitoring of blood sugar, kidney values, and blood counts is absolutely essential.
Streptozocin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。