Prednisolone
別名: Pred Forte, Pred Mild, Econopred, Econopred Plus, Mydrapred, PLT, Prednicare, Prednidale, Pred-forte
> **Crucial Step**: If you are using the **acetate suspension** (e.g., Pred Forte), you MUST shake the bottle vigorously before every single use. The medication settles at the bottom, and failing to shake it means you are only applying water to the eye. * **Administration**: Wash your hands before use. Do not let the dropper tip touch your pet's eye, eyelids, or any other surface to prevent contamination. * **Spacing**: If you are applying multiple types of eye drops, wait at least 5 to 10 minutes between each medication. * **Watch for Ulcers**: Steroids delay healing. If your pet's eye becomes more red, cloudy, or if they start squinting or rubbing the eye, **stop the medication and contact your veterinarian immediately**. This could indicate a corneal scratch or ulcer. * **Systemic Signs**: Even eye drops can be absorbed into the body. Monitor your pet for increased thirst, increased urination, or increased appetite, and report these to your vet.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Severe anterior uveitis
- Moderate to mild uveitis / Post-operative anterior segment surgery
- Feline IMHA Induction
- Severe anterior uveitis
- Moderate to mild uveitis / Post-operative anterior segment surgery
- Severe anterior uveitis
- Moderate to mild uveitis / Post-operative anterior segment surgery
- IMHA / IMTP Induction
- Steroid-responsive meningitis Induction
給藥方式
可能的副作用
- Systemic absorption leading to iatrogenic hyperadrenocorticism (PU/PD/PP, panting, alopecia)
- Insulin resistance and destabilization of diabetes mellitus
- Delayed corneal healing
- Potentiation or exacerbation of ocular infections (bacterial, viral, fungal)
- Corneal degeneration or calcification (with long-term topical use)
- Hypothalamic-pituitary axis (HPA) suppression
- Adrenal atrophy
- Proteinuria and glomerular changes (dogs)
- Weight loss and muscle atrophy (catabolic effects)
- Iatrogenic hyperadrenocorticism (Cushing's syndrome)
- Vomiting and diarrhoea
- Gastrointestinal ulceration
- Hyperglycaemia
注意事項與禁忌
- Corneal ulcers (absolute contraindication for topical use)
- Ocular viral infections (e.g., Feline Herpesvirus-1)
- Ocular fungal infections
- Use with extreme caution in patients with uncontrolled diabetes mellitus or systemic infectious diseases
- Pregnant animals
- Renal disease (systemic use)
- Diabetes mellitus (systemic use)
- Ulcerative keratitis (topical ophthalmic use)
- Systemic fungal infections
- Concurrent NSAID administration
- Corneal ulcers
- > **Important Warning**: Subconjunctival and topical steroids can be absorbed systemically. Use with extreme caution in patients with endocrinopathies (e.g., diabetes mellitus) or infectious diseases. Even frequent topical steroid application in small animal patients under 20 kg can cause difficulties with diabetes mellitus regulation. Once the peak inflammatory response has been suppressed, consider transitioning to nonsteroidal anti-inflammatory drugs (NSAIDs) for ongoing maintenance treatment to minimize systemic steroid exposure.
藥物相互作用
- Topical NSAIDs (e.g., flurbiprofen, diclofenac): Concurrent use may increase the risk of delayed corneal healing or corneal melting, though sometimes used together cautiously for severe inflammation.
- Insulin: Systemically absorbed prednisolone antagonizes insulin, increasing blood glucose and complicating diabetes regulation.
- Systemic NSAIDs: Increased risk of gastrointestinal ulceration if significant systemic absorption of prednisolone occurs.
- NSAIDs: Increased risk of gastrointestinal ulceration
- Acetazolamide: Increased risk of hypokalaemia
- Amphotericin B: Increased risk of hypokalaemia
- Potassium-depleting diuretics (e.g., furosemide, thiazides): Increased risk of hypokalaemia
- Phenytoin: Enhanced metabolism of corticosteroids
- Phenobarbital: Enhanced metabolism of corticosteroids
- Itraconazole: Decreased metabolism of corticosteroids
- Ciclosporin: Synergistic immunosuppression; may alter pharmacokinetics
常見問題
Prednisolone用於寵物有甚麼用途？
> **Crucial Step**: If you are using the **acetate suspension** (e.g., Pred Forte), you MUST shake the bottle vigorously before every single use. The medication settles at the bottom, and failing to shake it means you are only applying water to the eye. * **Administration**: Wash your hands before use. Do not let the dropper tip touch your pet's eye, eyelids, or any other surface to prevent contamination. * **Spacing**: If you are applying multiple types of eye drops, wait at least 5 to 10 minutes between each medication. * **Watch for Ulcers**: Steroids delay healing. If your pet's eye becomes more red, cloudy, or if they start squinting or rubbing the eye, **stop the medication and contact your veterinarian immediately**. This could indicate a corneal scratch or ulcer. * **Systemic Signs**: Even eye drops can be absorbed into the body. Monitor your pet for increased thirst, increased urination, or increased appetite, and report these to your vet.
Prednisolone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。