Piperacillin Sodium
別名: Pipracil, Pipril
* **Hospital Use**: Because this medication must be given by injection (IV, IM, or under the skin) and requires frequent dosing, it is usually administered while your pet is hospitalized. * **Purpose**: It is a powerful antibiotic often reserved for severe infections or bacteria that are resistant to more common drugs. * **Side Effects**: Generally very safe. Let your veterinarian know if your pet has ever had an allergic reaction to penicillin or cephalosporin antibiotics. Occasionally, it may cause mild stomach upset or diarrhea. * **Pain at Injection Site**: If given into the muscle, the injection can be temporarily painful.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For bacteremia with or without endocarditis
- For respiratory infections
- For susceptible infections
- For Bordetella avium infections
- For susceptible infections
- For empirical treatment in Psittacines of gram-negative bacterial infections
- For bacteremia with or without endocarditis
- For respiratory infections
- For systemic treatment of otitis media or proliferative otitis externa complicated by gram-negative (especially Pseudomonas) bacteria
- For susceptible infections
- For susceptible infections (Snakes)
給藥方式
可能的副作用
- Hypersensitivity reactions (allergic reactions)
- Local tissue irritation, pain at IM injection site
- Thrombophlebitis (with IV administration)
- Antibiotic-associated diarrhea (due to alterations in gut flora)
- Coagulation abnormalities (rare, mostly in renal failure)
- Neurotoxicity/seizures (at very high doses or in renal impairment)
- Clostridium difficile superinfections (rare)
注意事項與禁忌
- Patients with documented hypersensitivity to beta-lactam antibiotics (penicillins, cephalosporins)
- > **High Sodium Content**: Because of its sodium content (1.85 mEq per gram), high dosages may adversely affect patients with cardiac failure or hypernatremic conditions. * **Renal Impairment**: Dosage adjustment may be required in patients with significantly decreased renal function (CrCl <40 mL/min) to prevent neurotoxicity or coagulopathies. * **Laboratory Interference**: May cause false-positive urine glucose tests (cupric sulfate method) and false-positive direct Coombs' tests. Can falsely decrease aminoglycoside serum concentrations if samples are stored together prior to analysis.
藥物相互作用
- Aminoglycosides (amikacin, gentamicin, tobramycin): Synergistic against certain bacteria in vitro, but penicillins can chemically inactivate aminoglycosides in vivo (especially in renal failure or at massive doses). Do not mix in the same syringe/bag.
- Anticoagulants (heparin, warfarin): Piperacillin may rarely affect platelets; increased monitoring of coagulation parameters is suggested.
- Methotrexate: Piperacillin may increase methotrexate serum levels.
- Probenecid: Reduces renal tubular secretion of piperacillin, maintaining higher systemic levels for longer periods.
- Vecuronium: Piperacillin may prolong neuromuscular blockade.
常見問題
Piperacillin Sodium用於寵物有甚麼用途？
* **Hospital Use**: Because this medication must be given by injection (IV, IM, or under the skin) and requires frequent dosing, it is usually administered while your pet is hospitalized. * **Purpose**: It is a powerful antibiotic often reserved for severe infections or bacteria that are resistant to more common drugs. * **Side Effects**: Generally very safe. Let your veterinarian know if your pet has ever had an allergic reaction to penicillin or cephalosporin antibiotics. Occasionally, it may cause mild stomach upset or diarrhea. * **Pain at Injection Site**: If given into the muscle, the injection can be temporarily painful.
Piperacillin Sodium對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。