Neostigmine
別名: Prostigmin, Robinul-Neostigmine
This medication is used to help diagnose or treat a condition called **myasthenia gravis** (a disease causing severe muscle weakness), or to reverse certain muscle relaxants used during anesthesia. * **Watch closely for side effects:** If your pet begins drooling excessively, vomiting, having diarrhea, or showing signs of breathing difficulty or severe weakness, contact your veterinarian **immediately**. * This drug can cause a sudden drop in heart rate, so it is usually given in the clinic where your pet can be closely monitored. * Do not give any other medications without consulting your vet, as many drugs can interact with neostigmine.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Diagnosis of myasthenia gravis / Antagonism of non-depolarizing neuromuscular block
- Diagnosis of myasthenia gravis / Antagonism of non-depolarizing neuromuscular block
給藥方式
可能的副作用
- Nausea and vomiting
- Increased salivation (ptyalism)
- Diarrhoea
- Muscle fasciculations and cramps
- Weakness and paralysis (with overdose)
- Severe bradyarrhythmias or asystole
- Miosis and nystagmus
- Hypotension
- Bronchoconstriction and increased bronchial secretions
注意事項與禁忌
- Mechanical gastrointestinal obstruction
- Mechanical urinary tract obstruction
- Peritonitis
- Use with **extreme caution** in patients with: * **Bronchial disease** (especially feline asthma) * **Bradycardia** and other arrhythmias * **Hypotension** * **Renal impairment** * **Epilepsy** > Always have **atropine** (0.05 mg/kg IV) available for immediate administration when using neostigmine to diagnose myasthenia gravis.
藥物相互作用
- Aminoglycosides: May antagonize the neuromuscular effects of neostigmine
- Clindamycin: May antagonize the neuromuscular effects of neostigmine
- Halogenated inhalational anaesthetics: May antagonize the neuromuscular effects of neostigmine
- Quinine and related compounds: May increase clinical severity of myasthenia gravis and reduce neostigmine effectiveness
- Beta-blockers: May reduce effectiveness in myasthenia gravis; concurrent use may result in severe bradycardia
- Suxamethonium: Neostigmine inhibits its metabolism, prolonging and enhancing its clinical effect (combined use not recommended)
- Non-depolarizing muscle relaxants: Neostigmine antagonizes their effect (therapeutic use)
- Atropine: Antagonizes the muscarinic effects of neostigmine (used therapeutically to manage side effects)
常見問題
Neostigmine用於寵物有甚麼用途？
This medication is used to help diagnose or treat a condition called **myasthenia gravis** (a disease causing severe muscle weakness), or to reverse certain muscle relaxants used during anesthesia. * **Watch closely for side effects:** If your pet begins drooling excessively, vomiting, having diarrhea, or showing signs of breathing difficulty or severe weakness, contact your veterinarian **immediately**. * This drug can cause a sudden drop in heart rate, so it is usually given in the clinic where your pet can be closely monitored. * Do not give any other medications without consulting your vet, as many drugs can interact with neostigmine.
Neostigmine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。