Naproxen
別名: Naprosyn, Aleve, Anaprox, EC-Naprosyn, Midol Extended Relief, Naprelan, Equiproxen
> **DANGER**: Never give human over-the-counter pain relievers like Aleve® to your pets without explicit veterinary instructions. Naproxen is highly toxic to dogs and cats. * If your pet is prescribed naproxen, strictly adhere to the dosing schedule (which may be as infrequent as every other day for dogs). * **Stop the medication and contact your veterinarian immediately** if you notice: * Loss of appetite or lethargy/depression * Vomiting (especially if it contains blood or looks like coffee grounds) * Diarrhea or black, tarry stools * Changes in drinking or urination habits
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Myositis and soft tissue diseases of the musculoskeletal system
- Systemic therapies for joint disease
- Septic arthritis pain; inflammation (Rabbits)
- Osteoarthritis and musculoskeletal inflammatory diseases (Last resort)
給藥方式
可能的副作用
- GI distress (anorexia, vomiting, diarrhea)
- Gastrointestinal ulcers and perforation
- Melena and bloody vomitus
- Renal effects (nephritis, nephrotic syndrome, fluid retention)
- Hepatic effects (increased liver enzymes)
- Hematologic effects (hypoproteinemia, decreased hematocrit, anemia)
- CNS effects (neuropathies, lethargy, depression)
注意事項與禁忌
- Active GI ulcers
- History of hypersensitivity to naproxen or other NSAIDs
- Pre-existing hematologic, renal, or hepatic disease
- > **WARNING**: Extremely narrow therapeutic index in dogs. Use is generally discouraged unless all FDA-approved, safer NSAIDs have failed. * **Relatively Contraindicated**: Patients with a history of or pre-existing hematologic, renal, or hepatic disease. * **Caution**: Use cautiously in patients with a history of GI ulcers or heart failure (may cause fluid retention). * **Infection**: Animals suffering from inflammation secondary to concomitant infection should receive appropriate antimicrobial therapy alongside NSAID treatment.
藥物相互作用
- Aminoglycosides (gentamicin, amikacin): Increased risk for nephrotoxicity
- Anticoagulants (heparin, LMWH, warfarin): Increased risk for bleeding
- Aspirin: Decreased plasma levels of naproxen and increased likelihood of GI adverse effects (blood loss). Concomitant use is not recommended.
- Bisphosphonates (alendronate): May increase risk for GI ulceration
- Corticosteroids: Concomitant administration significantly increases the risks for GI adverse effects and ulceration
- Furosemide: Naproxen may reduce the saluretic and diuretic effects of furosemide
- Highly protein bound drugs (phenytoin, valproic acid, sulfonamides): Potential displacement leading to increased serum levels and duration of action of the displaced drug
- Methotrexate: Serious toxicity has occurred; use together with extreme caution
- Probenecid: May cause a significant increase in serum levels and half-life of naproxen
常見問題
Naproxen用於寵物有甚麼用途？
> **DANGER**: Never give human over-the-counter pain relievers like Aleve® to your pets without explicit veterinary instructions. Naproxen is highly toxic to dogs and cats. * If your pet is prescribed naproxen, strictly adhere to the dosing schedule (which may be as infrequent as every other day for dogs). * **Stop the medication and contact your veterinarian immediately** if you notice: * Loss of appetite or lethargy/depression * Vomiting (especially if it contains blood or looks like coffee grounds) * Diarrhea or black, tarry stools * Changes in drinking or urination habits
Naproxen對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。