Methimazole
別名: Tapazole, Felimazole, Northyx, Antitiroide, Danantizol, Favistan, Mercaptizol, Metibasol, Strumazol, Thacapzol, Thycapzol, Thyrozol, Tirodril, Unimazole, Thiafeline, Thyronorm
### Understanding Your Pet's Medication **Methimazole** is a daily medication used to manage hyperthyroidism (an overactive thyroid gland) in cats. - **How it works**: It blocks the production of excess thyroid hormones, helping your cat regain normal weight, heart rate, and behavior. - **Not a cure**: This medication *controls* the disease but does not cure it. Your cat will likely need this medication for life. - **Patience is key**: It may take 1 to 3 weeks to see noticeable improvement in your cat's symptoms. ### Administration Tips - The pills have a very bitter taste. Do not crush them unless instructed, as your cat may refuse to eat the food it is mixed with. - If you are struggling to pill your cat, ask your veterinarian about a **transdermal gel** that can be rubbed onto the hairless part of your cat's ear. ### Safety Warnings > **Human Safety**: Methimazole can affect human thyroid function and fetal development. **Pregnant women, women trying to conceive, and nursing mothers should wear gloves** when handling the medication, the cat's litter box, or bodily fluids. ### What to Watch For Contact your veterinarian immediately if your cat experiences: - Vomiting or loss of appetite (especially in the first few weeks) - Extreme lethargy or weakness - Intense scratching at the face or neck - Unexplained bruising or bleeding
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hyperthyroidism
- Hyperthyroidism (cats with azotemia or for clients declining radioiodine)
- Hyperthyroidism (transdermal administration)
- Hyperthyroidism (gradual titration)
- Hyperthyroidism (based on renal status)
- Hyperthyroidism
- Hyperthyroidism
- As an investigative method to reduce nephrotoxicity associated with cisplatin therapy
- Hyperthyroidism
給藥方式
可能的副作用
- Vomiting
- Anorexia
- Depression/Lethargy
- Transient eosinophilia, leukopenia, and lymphocytosis
- Self-induced facial excoriations (pruritus)
- Bleeding/Coagulopathies
- Hepatopathy
- Thrombocytopenia
- Agranulocytosis
- Positive direct antiglobulin test (DAT)
- Positive ANA (in chronic use >6 months)
- Acquired myasthenia gravis (rare)
- Inappetence / Anorexia
- Jaundice / Hepatopathy
注意事項與禁忌
- Hypersensitivity to methimazole, carbimazole, or polyethylene glycol
- Autoimmune disease
- Primary liver disease
- Renal failure
- Hematologic disorders or coagulopathies
- Pregnant or lactating queens
- Pregnant queens
- Lactating queens
- Animals with known hypersensitivity to thiamazole or carbimazole
- > **Black Box / Handling Warning**: Pregnant women, women who may become pregnant, and nursing mothers should wear gloves when handling tablets, litter, or bodily fluids of treated cats. - **Renal Unmasking**: Restoring euthyroidism can decrease glomerular filtration rate (GFR) and unmask underlying chronic kidney disease in cats. Careful monitoring of renal values is essential. - **Hematologic & Hepatic Monitoring**: Severe adverse effects like agranulocytosis and hepatotoxicity usually occur within the first 3 months. Routine bloodwork monitoring is critical during this phase. - **Nursing**: Kittens should be placed on a milk replacer if the mother is receiving the drug, as it is excreted in milk and can cause fetal/neonatal hypothyroidism.
藥物相互作用
- Benzimidazole antiparasitics: Methimazole can reduce hepatic oxidation of benzimidazoles and increase blood levels.
- Beta-blockers: A reduction in dose may be needed when the patient becomes euthyroid.
- Bupropion: Potential for increased risk for hepatotoxicity; increased monitoring (LFT's) necessary.
- Digoxin: Methimazole may decrease digoxin efficacy, but a reduction in dose may be needed when the patient becomes euthyroid.
- Phenobarbital: Concurrent use of phenobarbital may reduce the clinical effectiveness of methimazole.
- Theophylline: A reduction in dose may be needed when the patient becomes euthyroid.
- Warfarin: Anticoagulants may be potentiated by methimazole. Increased monitoring of anticoagulant effect is warranted.
- Benzimidazoles: Reduce hepatic oxidation and may lead to increased circulating thiamazole concentrations
- Iodine-131 (Radioiodine): Thiamazole interferes with radioiodine uptake; must be discontinued prior to I-131 treatment
- Low-iodine prescription diets: Concurrent use is not recommended as it confounds dietary management and iodine restriction
常見問題
Methimazole用於寵物有甚麼用途？
### Understanding Your Pet's Medication **Methimazole** is a daily medication used to manage hyperthyroidism (an overactive thyroid gland) in cats. - **How it works**: It blocks the production of excess thyroid hormones, helping your cat regain normal weight, heart rate, and behavior. - **Not a cure**: This medication *controls* the disease but does not cure it. Your cat will likely need this medication for life. - **Patience is key**: It may take 1 to 3 weeks to see noticeable improvement in your cat's symptoms. ### Administration Tips - The pills have a very bitter taste. Do not crush them unless instructed, as your cat may refuse to eat the food it is mixed with. - If you are struggling to pill your cat, ask your veterinarian about a **transdermal gel** that can be rubbed onto the hairless part of your cat's ear. ### Safety Warnings > **Human Safety**: Methimazole can affect human thyroid function and fetal development. **Pregnant women, women trying to conceive, and nursing mothers should wear gloves** when handling the medication, the cat's litter box, or bodily fluids. ### What to Watch For Contact your veterinarian immediately if your cat experiences: - Vomiting or loss of appetite (especially in the first few weeks) - Extreme lethargy or weakness - Intense scratching at the face or neck - Unexplained bruising or bleeding
Methimazole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。