甲巰咪唑
別名: Tapazole, Felimazole, Northyx, Antitiroide, Danantizol, Favistan, Mercaptizol, Metibasol, Strumazol, Thacapzol, Thycapzol, Thyrozol, Tirodril, Unimazole, Thiafeline, Thyronorm
### 了解您寵物的藥物 **甲巰咪唑 (Methimazole)** 是一種用於控制貓咪甲狀腺機能亢進（甲狀腺過度活躍）的日常藥物。 - **作用原理**：它能阻斷過多甲狀腺激素的產生，幫助您的貓咪恢復正常的體重、心率和行為。 - **非治癒性**：此藥物能*控制*疾病，但無法治癒。您的貓咪可能需要終身服用此藥。 - **需要耐心**：通常需要 1 到 3 週的時間才能看到貓咪症狀有明顯改善。 ### 餵藥技巧 - 藥丸有非常苦的味道。除非獸醫師指示，否則請勿將其壓碎，因為貓咪可能會拒絕食用混有藥粉的食物。 - 如果您在餵食藥丸時遇到困難，請向您的獸醫師詢問**經皮吸收凝膠**，這是一種可以塗抹在貓咪耳朵無毛處的替代劑型。 ### 安全警告 > **人類安全**：甲巰咪唑會影響人類的甲狀腺功能和胎兒發育。**孕婦、準備懷孕的女性及哺乳期婦女在接觸藥丸、貓砂或治療貓咪的體液時，應戴上手套**。 ### 注意事項 如果您的貓咪出現以下情況，請立即聯繫您的獸醫師： - 嘔吐或食慾不振（尤其是在最初幾週內） - 極度嗜睡或虛弱 - 劇烈抓撓臉部或頸部 - 不明原因的瘀傷或出血
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Hyperthyroidism
- Hyperthyroidism (cats with azotemia or for clients declining radioiodine)
- Hyperthyroidism (transdermal administration)
- Hyperthyroidism (gradual titration)
- Hyperthyroidism (based on renal status)
- Hyperthyroidism
- Hyperthyroidism
- As an investigative method to reduce nephrotoxicity associated with cisplatin therapy
- Hyperthyroidism
給藥方式
可能的副作用
- Vomiting
- Anorexia
- Depression/Lethargy
- Transient eosinophilia, leukopenia, and lymphocytosis
- Self-induced facial excoriations (pruritus)
- Bleeding/Coagulopathies
- Hepatopathy
- Thrombocytopenia
- Agranulocytosis
- Positive direct antiglobulin test (DAT)
- Positive ANA (in chronic use >6 months)
- Acquired myasthenia gravis (rare)
- Inappetence / Anorexia
- Jaundice / Hepatopathy
- Cytopenias (thrombocytopenia, leukopenia, anemia)
- Immune-mediated diseases (e.g., myasthenia gravis)
- Dermatological changes (pruritus, facial excoriation, alopecia)
- Decreased GFR (unmasking of renal failure)
注意事項與禁忌
- Hypersensitivity to methimazole, carbimazole, or polyethylene glycol
- Autoimmune disease
- Primary liver disease
- Renal failure
- Hematologic disorders or coagulopathies
- Pregnant or lactating queens
- Pregnant queens
- Lactating queens
- Animals with known hypersensitivity to thiamazole or carbimazole
- > **Black Box / Handling Warning**: Pregnant women, women who may become pregnant, and nursing mothers should wear gloves when handling tablets, litter, or bodily fluids of treated cats. - **Renal Unmasking**: Restoring euthyroidism can decrease glomerular filtration rate (GFR) and unmask underlying chronic kidney disease in cats. Careful monitoring of renal values is essential. - **Hematologic & Hepatic Monitoring**: Severe adverse effects like agranulocytosis and hepatotoxicity usually occur within the first 3 months. Routine bloodwork monitoring is critical during this phase. - **Nursing**: Kittens should be placed on a milk replacer if the mother is receiving the drug, as it is excreted in milk and can cause fetal/neonatal hypothyroidism.
藥物相互作用
- Benzimidazole antiparasitics: Methimazole can reduce hepatic oxidation of benzimidazoles and increase blood levels.
- Beta-blockers: A reduction in dose may be needed when the patient becomes euthyroid.
- Bupropion: Potential for increased risk for hepatotoxicity; increased monitoring (LFT's) necessary.
- Digoxin: Methimazole may decrease digoxin efficacy, but a reduction in dose may be needed when the patient becomes euthyroid.
- Phenobarbital: Concurrent use of phenobarbital may reduce the clinical effectiveness of methimazole.
- Theophylline: A reduction in dose may be needed when the patient becomes euthyroid.
- Warfarin: Anticoagulants may be potentiated by methimazole. Increased monitoring of anticoagulant effect is warranted.
- Benzimidazoles: Reduce hepatic oxidation and may lead to increased circulating thiamazole concentrations
- Iodine-131 (Radioiodine): Thiamazole interferes with radioiodine uptake; must be discontinued prior to I-131 treatment
- Low-iodine prescription diets: Concurrent use is not recommended as it confounds dietary management and iodine restriction
常見問題
甲巰咪唑用於寵物有甚麼用途？
### 了解您寵物的藥物 甲巰咪唑 (Methimazole) 是一種用於控制貓咪甲狀腺機能亢進（甲狀腺過度活躍）的日常藥物。 - 作用原理：它能阻斷過多甲狀腺激素的產生，幫助您的貓咪恢復正常的體重、心率和行為。 - 非治癒性：此藥物能*控制*疾病，但無法治癒。您的貓咪可能需要終身服用此藥。 - 需要耐心：通常需要 1 到 3 週的時間才能看到貓咪症狀有明顯改善。 ### 餵藥技巧 - 藥丸有非常苦的味道。除非獸醫師指示，否則請勿將其壓碎，因為貓咪可能會拒絕食用混有藥粉的食物。 - 如果您在餵食藥丸時遇到困難，請向您的獸醫師詢問經皮吸收凝膠，這是一種可以塗抹在貓咪耳朵無毛處的替代劑型。 ### 安全警告 > 人類安全：甲巰咪唑會影響人類的甲狀腺功能和胎兒發育。孕婦、準備懷孕的女性及哺乳期婦女在接觸藥丸、貓砂或治療貓咪的體液時，應戴上手套。 ### 注意事項 如果您的貓咪出現以下情況，請立即聯繫您的獸醫師： - 嘔吐或食慾不振（尤其是在最初幾週內） - 極度嗜睡或虛弱 - 劇烈抓撓臉部或頸部 - 不明原因的瘀傷或出血
甲巰咪唑對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。