Mavacoxib
別名: Trocoxil
> **CRITICAL WARNING:** This is **NOT** a daily medication. Give exactly as directed by your veterinarian (typically a dose on Day 1, Day 14, and then strictly once a month). Do not give extra doses. * **Give with Food:** Must be given with the dog's largest meal of the day. The drug is much better absorbed from the stomach if given with food. * **Watch for Side Effects:** Contact your veterinarian immediately if you notice loss of appetite, vomiting, bloody or dark/tarry stools, changes in behavior, or changes in drinking/urination. *Note: Because this drug lasts a long time in the body, side effects could potentially occur weeks after the last dose was given.* * **Safe Storage:** These chewable tablets are highly palatable to dogs. Store them strictly out of reach of all animals and children to prevent accidental overdose.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Any
- Pain and inflammation associated with degenerative joint disease in dogs aged 12 months or more in cases where continuous treatment exceeding one month is indicated
- Pain and inflammation associated with degenerative joint disease (osteoarthritis)
給藥方式
可能的副作用
- Inappetence
- Diarrhea
- Vomiting
- Depression
- Renal toxicity
- Gastrointestinal ulceration
- Gastrointestinal ulceration or bleeding
- Vomiting and diarrhoea
- Renal toxicity (especially if dehydrated or hypotensive)
- Hepatic accumulation (in poor metabolizers)
- Theoretical risk of precipitating cardiac failure
注意事項與禁忌
- Dogs less than 12 months of age
- Dogs less than 5 kg body weight
- Gastrointestinal disorders including ulceration and bleeding
- Evidence of a hemorrhagic disorder
- Impaired renal or hepatic function
- Cardiac insufficiency
- Hypersensitivity to mavacoxib, sulfonamides, or excipients
- Pregnant, breeding, or lactating animals
- Dehydrated, hypovolemic, or hypotensive animals
- Dehydrated, hypovolaemic, or hypotensive patients
- Gastrointestinal disease or ulceration
- Blood clotting disorders
- Liver disease (prolongs metabolism and causes accumulation)
藥物相互作用
- ACE Inhibitors (e.g., enalapril, benazepril): NSAIDs can reduce effects on blood pressure and potentially reduce renal blood flow, increasing the risk for renal injury.
- Aspirin: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea). Long washout periods are warranted when switching.
- Corticosteroids (e.g., prednisone): May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea). Concurrent use is contraindicated.
- Digoxin: NSAIDs may increase serum levels of digoxin.
- Fluconazole: May increase plasma levels of mavacoxib (extrapolated from celecoxib data in humans).
- Furosemide: NSAIDs may reduce saluretic and diuretic effects.
- Methotrexate: Serious toxicity has occurred when NSAIDs have been used concomitantly; use together with extreme caution.
- Nephrotoxic Drugs (e.g., aminoglycosides, amphotericin B): May enhance the risk of nephrotoxicity development.
- Other NSAIDs: May increase the risk of gastrointestinal toxicity. Do not administer other NSAIDs within 1 month of the last administration of mavacoxib.
常見問題
Mavacoxib用於寵物有甚麼用途？
> **CRITICAL WARNING:** This is **NOT** a daily medication. Give exactly as directed by your veterinarian (typically a dose on Day 1, Day 14, and then strictly once a month). Do not give extra doses. * **Give with Food:** Must be given with the dog's largest meal of the day. The drug is much better absorbed from the stomach if given with food. * **Watch for Side Effects:** Contact your veterinarian immediately if you notice loss of appetite, vomiting, bloody or dark/tarry stools, changes in behavior, or changes in drinking/urination. *Note: Because this drug lasts a long time in the body, side effects could potentially occur weeks after the last dose was given.* * **Safe Storage:** These chewable tablets are highly palatable to dogs. Store them strictly out of reach of all animals and children to prevent accidental overdose.
Mavacoxib對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。