Isosorbide Dinitrate / Isosorbide Mononitrate
別名: Isordil, Ismo, Imdur, Isochron, Dilatrate-SR, Monoket, Titradose
* **Experimental Nature:** There is limited experience using this medication in veterinary medicine; it is typically reserved for advanced or difficult-to-treat heart conditions. * **Administration:** May be given with or without meals. Follow your veterinarian's dosing schedule exactly, as specific timing may be needed to prevent the body from building a tolerance to the drug. * **What to Watch For:** Because this drug lowers blood pressure, watch your pet closely for signs of weakness, lethargy, stumbling, or fainting. If these occur, contact your veterinarian immediately. * **Storage:** Keep the medication tightly closed in its original container, protected from heat and moisture, as these can cause the drug to lose its potency.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of heart failure associated with thyroid storm
- Refractory heart failure or in combination with hydralazine or amlodipine in patients unable to tolerate ACE inhibitors
- Refractory heart failure or in combination with hydralazine or amlodipine in patients unable to tolerate ACE inhibitors
給藥方式
可能的副作用
- Postural hypotension
- Reflex tachycardia
- Lethargy or weakness (secondary to hypotension)
- Gastrointestinal upset
- Restlessness
- Headache (well-documented in humans, difficult to assess in animals)
- Hypersensitivity reactions (rare)
注意事項與禁忌
- Cardiogenic or hypovolemic shock
- Severe hypotension
- Hypovolemia
- Use as a sole agent for treating heart failure
- Concurrent use with selective phosphodiesterase inhibitors (e.g., sildenafil)
- > **Hemodynamic Warning:** Use with extreme caution in patients with low blood pressure or uncorrected hypovolemia. * **Nitrate Tolerance:** Continuous exposure may lead to tolerance. Consider dosing strategies that allow for a nitrate-free interval if chronic use is intended. * **Laboratory Interference:** Serum cholesterol levels may be falsely decreased by nitrates when using the Zlatkis-Zak color reaction method. * **Pregnancy:** FDA Category C. Use only if the potential benefit justifies the potential risk to the fetus.
藥物相互作用
- Antihypertensive Drugs (e.g., ACE inhibitors, amlodipine, beta-blockers): Possible additive hypotensive effects; monitor blood pressure closely.
- Phenothiazines (e.g., acepromazine): Possible additive hypotensive effects due to alpha-adrenergic blockade.
- Selective Phosphodiesterase Inhibitors (e.g., sildenafil, pimobendan): Concurrent use with sildenafil can cause profound, life-threatening hypotension and is strictly contraindicated. Use with pimobendan (a PDE3 inhibitor) is common in vet med but requires monitoring for excessive vasodilation.
常見問題
Isosorbide Dinitrate / Isosorbide Mononitrate用於寵物有甚麼用途？
* **Experimental Nature:** There is limited experience using this medication in veterinary medicine; it is typically reserved for advanced or difficult-to-treat heart conditions. * **Administration:** May be given with or without meals. Follow your veterinarian's dosing schedule exactly, as specific timing may be needed to prevent the body from building a tolerance to the drug. * **What to Watch For:** Because this drug lowers blood pressure, watch your pet closely for signs of weakness, lethargy, stumbling, or fainting. If these occur, contact your veterinarian immediately. * **Storage:** Keep the medication tightly closed in its original container, protected from heat and moisture, as these can cause the drug to lose its potency.
Isosorbide Dinitrate / Isosorbide Mononitrate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。