Isosorbide Dinitrate / Isosorbide Mononitrate
別名: Isordil, Ismo, Imdur, Isochron, Dilatrate-SR, Monoket, Titradose
* **Experimental Nature:** There is limited experience using this medication in veterinary medicine; it is typically reserved for advanced or difficult-to-treat heart conditions. * **Administration:** May be given with or without meals. Follow your veterinarian's dosing schedule exactly, as specific timing may be needed to prevent the body from building a tolerance to the drug. * **What to Watch For:** Because this drug lowers blood pressure, watch your pet closely for signs of weakness, lethargy, stumbling, or fainting. If these occur, contact your veterinarian immediately. * **Storage:** Keep the medication tightly closed in its original container, protected from heat and moisture, as these can cause the drug to lose its potency.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Adjunctive treatment of heart failure associated with thyroid storm
- Refractory heart failure or in combination with hydralazine or amlodipine in patients unable to tolerate ACE inhibitors
- Refractory heart failure or in combination with hydralazine or amlodipine in patients unable to tolerate ACE inhibitors
給藥方式
可能的副作用
- Postural hypotension
- Reflex tachycardia
- Lethargy or weakness (secondary to hypotension)
- Gastrointestinal upset
- Restlessness
- Headache (well-documented in humans, difficult to assess in animals)
- Hypersensitivity reactions (rare)
注意事項與禁忌
- Cardiogenic or hypovolemic shock
- Severe hypotension
- Hypovolemia
- Use as a sole agent for treating heart failure
- Concurrent use with selective phosphodiesterase inhibitors (e.g., sildenafil)
- > **Hemodynamic Warning:** Use with extreme caution in patients with low blood pressure or uncorrected hypovolemia. * **Nitrate Tolerance:** Continuous exposure may lead to tolerance. Consider dosing strategies that allow for a nitrate-free interval if chronic use is intended. * **Laboratory Interference:** Serum cholesterol levels may be falsely decreased by nitrates when using the Zlatkis-Zak color reaction method. * **Pregnancy:** FDA Category C. Use only if the potential benefit justifies the potential risk to the fetus.
藥物相互作用
- Antihypertensive Drugs (e.g., ACE inhibitors, amlodipine, beta-blockers): Possible additive hypotensive effects; monitor blood pressure closely.
- Phenothiazines (e.g., acepromazine): Possible additive hypotensive effects due to alpha-adrenergic blockade.
- Selective Phosphodiesterase Inhibitors (e.g., sildenafil, pimobendan): Concurrent use with sildenafil can cause profound, life-threatening hypotension and is strictly contraindicated. Use with pimobendan (a PDE3 inhibitor) is common in vet med but requires monitoring for excessive vasodilation.
常見問題
Isosorbide Dinitrate / Isosorbide Mononitrate用於寵物有甚麼用途？
* **Experimental Nature:** There is limited experience using this medication in veterinary medicine; it is typically reserved for advanced or difficult-to-treat heart conditions. * **Administration:** May be given with or without meals. Follow your veterinarian's dosing schedule exactly, as specific timing may be needed to prevent the body from building a tolerance to the drug. * **What to Watch For:** Because this drug lowers blood pressure, watch your pet closely for signs of weakness, lethargy, stumbling, or fainting. If these occur, contact your veterinarian immediately. * **Storage:** Keep the medication tightly closed in its original container, protected from heat and moisture, as these can cause the drug to lose its potency.
Isosorbide Dinitrate / Isosorbide Mononitrate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。