Estradiol Cypionate
別名: Delestrogen, DepoEstradiol, Depogen, Dura-Estrin, ECP, E-Cypionate, Estra-D, Estrace, Estro-Cyp, Estroject, depGynogen, Femtrace, Gynodiol
- **Severe Risk Warning:** This medication can cause severe, sometimes fatal, damage to the bone marrow in dogs and cats. It is rarely used today for this reason. - Contact your veterinarian **immediately** if your pet shows signs of anemia or bleeding, such as **pale gums, unusual bruising, pinpoint red spots on the skin, or extreme lethargy**. - Watch closely for signs of a severe uterine infection (**pyometra**), which include drinking excessive amounts of water, frequent urination, lethargy, or vaginal discharge. This can occur 1 to 6 weeks after treatment. - **Do not use in pregnant animals**, as it causes severe birth defects. - **Illegal in food animals:** This drug must never be used in animals intended for human consumption.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Pregnancy avoidance after mismating
- Any
- To enhance estrus behavior and receptivity in ovariectomized mares
- Treatment of mares with estrogen-responsive incontinence
- Pregnancy avoidance after mismating
給藥方式
可能的副作用
- Bone marrow toxicity (thrombocytopenia, leukopenia, fatal aplastic anemia)
- Cystic endometrial hyperplasia
- Pyometra
- Mammary neoplasia
- Feminization (in males)
- Prolonged estrus (in females)
- Genital irritation (cattle)
- Decreased milk flow (cattle)
- Follicular cysts (cattle)
注意事項與禁忌
- Pregnancy (teratogenic and causes fetal bone marrow depression)
- Food-producing animals (illegal per FDA)
- Ferrets (highly susceptible to severe bone marrow toxicity)
- Estrogen-responsive incontinence in small animals (safer alternatives like DES or estriol should be used)
- Use with extreme caution in small animals due to the high risk of **blood dyscrasias** (bone marrow depression), which are more prevalent in older animals and at higher dosages. Toxicity can progress to fatal aplastic anemia. In cows with a prolonged corpus luteum, rule out endometritis or pregnancy before use. **Do not use in ferrets** due to extreme sensitivity to estrogen-induced bone marrow toxicity.
藥物相互作用
- Azole Antifungals (fluconazole, itraconazole, ketoconazole): May increase estrogen levels due to CYP450 enzyme inhibition.
- Corticosteroids: Enhanced glucocorticoid effects; estrogens may alter protein binding or decrease metabolism of corticosteroids.
- Macrolide Antibiotics (erythromycin, clarithromycin): May increase estrogen levels.
- Phenobarbital: May decrease estrogen activity via hepatic enzyme induction.
- Rifampin: May decrease estrogen activity via hepatic enzyme induction.
- St. John's Wort: May decrease estrogen activity.
- Warfarin: Oral anticoagulant activity may be decreased; dosage adjustments may be necessary.
常見問題
Estradiol Cypionate用於寵物有甚麼用途？
- **Severe Risk Warning:** This medication can cause severe, sometimes fatal, damage to the bone marrow in dogs and cats. It is rarely used today for this reason. - Contact your veterinarian **immediately** if your pet shows signs of anemia or bleeding, such as **pale gums, unusual bruising, pinpoint red spots on the skin, or extreme lethargy**. - Watch closely for signs of a severe uterine infection (**pyometra**), which include drinking excessive amounts of water, frequent urination, lethargy, or vaginal discharge. This can occur 1 to 6 weeks after treatment. - **Do not use in pregnant animals**, as it causes severe birth defects. - **Illegal in food animals:** This drug must never be used in animals intended for human consumption.
Estradiol Cypionate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。