環戊丙酸雌二醇
別名: Delestrogen, DepoEstradiol, Depogen, Dura-Estrin, ECP, E-Cypionate, Estra-D, Estrace, Estro-Cyp, Estroject, depGynogen, Femtrace, Gynodiol
- **極度危險警告**：此藥物可能對貓狗的骨髓造成嚴重且有時是致命的損害，因此現今已極少使用。 - 如果您的寵物出現貧血或出血跡象，例如**牙齦蒼白、異常瘀斑、皮膚出現紅色出血點或極度疲倦**，請**立即**聯繫獸醫。 - 密切觀察是否有嚴重的子宮感染（**子宮蓄膿**）跡象，包括：飲水量異常增加、頻尿、精神沉鬱或陰道分泌物。這可能在治療後 1 到 6 週內發生。 - **絕對不可用於懷孕動物**，會導致嚴重的胎兒畸形。 - **產食動物禁用**：此藥物絕不能用於供人類食用的動物。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Pregnancy avoidance after mismating
- Any
- To enhance estrus behavior and receptivity in ovariectomized mares
- Treatment of mares with estrogen-responsive incontinence
- Pregnancy avoidance after mismating
給藥方式
可能的副作用
- Bone marrow toxicity (thrombocytopenia, leukopenia, fatal aplastic anemia)
- Cystic endometrial hyperplasia
- Pyometra
- Mammary neoplasia
- Feminization (in males)
- Prolonged estrus (in females)
- Genital irritation (cattle)
- Decreased milk flow (cattle)
- Follicular cysts (cattle)
注意事項與禁忌
- Pregnancy (teratogenic and causes fetal bone marrow depression)
- Food-producing animals (illegal per FDA)
- Ferrets (highly susceptible to severe bone marrow toxicity)
- Estrogen-responsive incontinence in small animals (safer alternatives like DES or estriol should be used)
- Use with extreme caution in small animals due to the high risk of **blood dyscrasias** (bone marrow depression), which are more prevalent in older animals and at higher dosages. Toxicity can progress to fatal aplastic anemia. In cows with a prolonged corpus luteum, rule out endometritis or pregnancy before use. **Do not use in ferrets** due to extreme sensitivity to estrogen-induced bone marrow toxicity.
藥物相互作用
- Azole Antifungals (fluconazole, itraconazole, ketoconazole): May increase estrogen levels due to CYP450 enzyme inhibition.
- Corticosteroids: Enhanced glucocorticoid effects; estrogens may alter protein binding or decrease metabolism of corticosteroids.
- Macrolide Antibiotics (erythromycin, clarithromycin): May increase estrogen levels.
- Phenobarbital: May decrease estrogen activity via hepatic enzyme induction.
- Rifampin: May decrease estrogen activity via hepatic enzyme induction.
- St. John's Wort: May decrease estrogen activity.
- Warfarin: Oral anticoagulant activity may be decreased; dosage adjustments may be necessary.
常見問題
環戊丙酸雌二醇用於寵物有甚麼用途？
- 極度危險警告：此藥物可能對貓狗的骨髓造成嚴重且有時是致命的損害，因此現今已極少使用。 - 如果您的寵物出現貧血或出血跡象，例如牙齦蒼白、異常瘀斑、皮膚出現紅色出血點或極度疲倦，請立即聯繫獸醫。 - 密切觀察是否有嚴重的子宮感染（子宮蓄膿）跡象，包括：飲水量異常增加、頻尿、精神沉鬱或陰道分泌物。這可能在治療後 1 到 6 週內發生。 - 絕對不可用於懷孕動物，會導致嚴重的胎兒畸形。 - 產食動物禁用：此藥物絕不能用於供人類食用的動物。
環戊丙酸雌二醇對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。