去氧皮質酮特戊酸酯 (DOCP)
別名: Percorten-V, Cortiron, Zycortal
藥物類別: Mineralocorticoid
* **注意愛迪生氏症危機：** 飼主應熟悉與腎上腺皮質機能減退症相關的症狀（例如：虛弱、抑鬱、厭食、嘔吐、腹瀉等），若出現這些情況，請立即聯繫獸醫。 * **注意藥物過量：** 藥物過量的跡象包括過度口渴和排尿 (PU/PD)、水腫或體重快速增加。 * **壓力期劑量調整：** 在面臨壓力事件（如寄宿、看獸醫、生病）時，您的寵物可能需要額外口服類固醇（如潑尼松）。 * **居家注射：** 如果在家中注射，抽藥前請**用力搖晃藥瓶**，確保巨結晶完全懸浮。請確保掌握正確的肌肉注射 (IM) 或皮下注射 (SC) 技巧。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Maintenance therapy of hypoadrenocorticism
- Maintenance therapy of hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
給藥方式
IMSC
可能的副作用
- Injection site irritation
- Polyuria (PU)
- Polydipsia (PD)
- Hypernatremia
- Hypokalemia
- Hypertension
- Edema
- Weight gain (fluid retention)
注意事項與禁忌
- Congestive heart failure
- Severe renal disease
- Edema
- > **CRITICAL WARNING:** Do **NOT** administer intravenously (IV). Acute collapse and shock may result. If given IV, treat immediately for shock with IV fluids and glucocorticoids. * **Glucocorticoid Supplementation:** DOCP lacks glucocorticoid activity. All animals with hypoadrenocorticism should receive additional glucocorticoids (2-10 times basal) during periods of stress or acute illness. * **Contraindications:** Contraindicated in dogs suffering from congestive heart failure, severe renal disease, or edema. * **Pregnancy:** Use in pregnant animals only when potential benefits outweigh risks (safe use not established). Safe for nursing offspring. * **Individualized Dosing:** 'Cookbook' dosing without ongoing monitoring is inappropriate due to variable sensitivity.
藥物相互作用
- Amphotericin B: Patients may develop hypokalemia if mineralocorticoids are administered concomitantly.
- Aspirin: DOCP may reduce salicylate levels.
- Digoxin: Because DOCP may cause hypokalemia, it should be used with caution and increased monitoring when used in patients receiving digitalis glycosides.
- Insulin: Potentially, DOCP could increase the insulin requirements of diabetic patients.
- Potassium-depleting diuretics (e.g., furosemide, thiazides): Patients may develop hypokalemia if administered concomitantly; as diuretics can cause a loss of sodium, they may counteract the effects of DOCP.
常見問題
去氧皮質酮特戊酸酯 (DOCP)用於寵物有甚麼用途？
• 注意愛迪生氏症危機： 飼主應熟悉與腎上腺皮質機能減退症相關的症狀（例如：虛弱、抑鬱、厭食、嘔吐、腹瀉等），若出現這些情況，請立即聯繫獸醫。 • 注意藥物過量： 藥物過量的跡象包括過度口渴和排尿 (PU/PD)、水腫或體重快速增加。 • 壓力期劑量調整： 在面臨壓力事件（如寄宿、看獸醫、生病）時，您的寵物可能需要額外口服類固醇（如潑尼松）。 • 居家注射： 如果在家中注射，抽藥前請用力搖晃藥瓶，確保巨結晶完全懸浮。請確保掌握正確的肌肉注射 (IM) 或皮下注射 (SC) 技巧。
去氧皮質酮特戊酸酯 (DOCP)對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。