Desoxycorticosterone Pivalate (DOCP)
別名: Percorten-V, Cortiron, Zycortal
* **Watch for Addisonian Crisis:** Clients should be familiar with the symptoms associated with hypoadrenocorticism (e.g., weakness, depression, anorexia, vomiting, diarrhea) and report these to the veterinarian immediately. * **Watch for Overdose:** Signs of too much medication include excessive thirst and urination (PU/PD), swelling/edema, or rapid weight gain. * **Stress Dosing:** Your pet will likely need extra oral steroids (like prednisone) during stressful events (boarding, vet visits, illness). * **At-Home Injections:** If administering at home, **shake the vial vigorously** before drawing up the dose to ensure the macrocrystals are fully suspended. Ensure proper intramuscular (IM) or subcutaneous (SC) technique.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Maintenance therapy of hypoadrenocorticism
- Maintenance therapy of hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
- Hypoadrenocorticism
給藥方式
可能的副作用
- Injection site irritation
- Polyuria (PU)
- Polydipsia (PD)
- Hypernatremia
- Hypokalemia
- Hypertension
- Edema
- Weight gain (fluid retention)
注意事項與禁忌
- Congestive heart failure
- Severe renal disease
- Edema
- > **CRITICAL WARNING:** Do **NOT** administer intravenously (IV). Acute collapse and shock may result. If given IV, treat immediately for shock with IV fluids and glucocorticoids. * **Glucocorticoid Supplementation:** DOCP lacks glucocorticoid activity. All animals with hypoadrenocorticism should receive additional glucocorticoids (2-10 times basal) during periods of stress or acute illness. * **Contraindications:** Contraindicated in dogs suffering from congestive heart failure, severe renal disease, or edema. * **Pregnancy:** Use in pregnant animals only when potential benefits outweigh risks (safe use not established). Safe for nursing offspring. * **Individualized Dosing:** 'Cookbook' dosing without ongoing monitoring is inappropriate due to variable sensitivity.
藥物相互作用
- Amphotericin B: Patients may develop hypokalemia if mineralocorticoids are administered concomitantly.
- Aspirin: DOCP may reduce salicylate levels.
- Digoxin: Because DOCP may cause hypokalemia, it should be used with caution and increased monitoring when used in patients receiving digitalis glycosides.
- Insulin: Potentially, DOCP could increase the insulin requirements of diabetic patients.
- Potassium-depleting diuretics (e.g., furosemide, thiazides): Patients may develop hypokalemia if administered concomitantly; as diuretics can cause a loss of sodium, they may counteract the effects of DOCP.
常見問題
Desoxycorticosterone Pivalate (DOCP)用於寵物有甚麼用途？
* **Watch for Addisonian Crisis:** Clients should be familiar with the symptoms associated with hypoadrenocorticism (e.g., weakness, depression, anorexia, vomiting, diarrhea) and report these to the veterinarian immediately. * **Watch for Overdose:** Signs of too much medication include excessive thirst and urination (PU/PD), swelling/edema, or rapid weight gain. * **Stress Dosing:** Your pet will likely need extra oral steroids (like prednisone) during stressful events (boarding, vet visits, illness). * **At-Home Injections:** If administering at home, **shake the vial vigorously** before drawing up the dose to ensure the macrocrystals are fully suspended. Ensure proper intramuscular (IM) or subcutaneous (SC) technique.
Desoxycorticosterone Pivalate (DOCP)對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。