Dapsone
別名: Avlosulfone, Daps, Dapsoderm-X, Dopsan, Novasulfone, Servidapsone, Sulfona
- **Strict Monitoring**: This medication requires close veterinary supervision. Frequent blood tests are necessary to monitor your pet's liver and red blood cells. - **Watch for Toxicity**: Contact your veterinarian immediately if you notice **pale or bluish gums**, **yellowing of the eyes/skin (jaundice)**, extreme lethargy, rapid breathing, vomiting, or unusual weakness. - **Sun Protection**: Dapsone can cause **photosensitivity**. Protect your pet's exposed skin from prolonged sunlight. - **Cats**: If prescribed for a cat, understand that the risks of severe side effects are significantly higher.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Alternative to clofazimine for treating feline leprosy
- Treating mycobacteriosis
- Aural chondritis
- Alternative treatment for Pneumocystis carinii pneumonia
- Alternative treatment for pemphigus
- Post-vaccination alopecia/vasculitis resistant to prednisone therapy
- Treating mycobacteriosis
- Adjunctive therapy of vasculitis
- Adjunctive treatment of Brown Recluse spider (Loxosceles spp.) bite
給藥方式
可能的副作用
- Hepatotoxicity
- Dose-dependent methemoglobinemia
- Hemolytic anemia
- Thrombocytopenia
- Neutropenias
- Gastrointestinal effects (nausea, vomiting)
- Neuropathies
- Cutaneous drug eruptions
- Photosensitivity
- Potential carcinogen
注意事項與禁忌
- Cats (relatively contraindicated due to high risk of neurotoxicity and hemolytic anemia)
- Hypersensitivity to dapsone or other sulfone drugs
- Patients with severe anemias or preexisting blood dyscrasias
- Preexisting hepatic dysfunction (use with extreme caution)
- - **Feline Sensitivity**: Cats are highly susceptible to dapsone-induced blood dyscrasias and hepatotoxicity. Use is generally not recommended. - **Pregnancy**: FDA Category C. Animal studies have shown adverse effects on the fetus. Use with caution in pregnant animals. - **Nursing**: Excreted into milk in concentrations equivalent to plasma; hemolytic reactions have been seen in human neonates. Consider switching to milk replacer if required in a nursing dam. - **Hepatic Disease**: Use with caution in animals with preexisting hepatic dysfunction due to hepatotoxic potential.
藥物相互作用
- Probenecid: May decrease the renal excretion of active metabolites of dapsone.
- Pyrimethamine: May increase risk of hematologic reactions occurring with dapsone.
- Rifampin: May decrease plasma dapsone concentrations (7-10 fold).
- Trimethoprim: May increase plasma dapsone concentrations (and vice versa) and potentially increase each other's toxicity.
常見問題
Dapsone用於寵物有甚麼用途？
- **Strict Monitoring**: This medication requires close veterinary supervision. Frequent blood tests are necessary to monitor your pet's liver and red blood cells. - **Watch for Toxicity**: Contact your veterinarian immediately if you notice **pale or bluish gums**, **yellowing of the eyes/skin (jaundice)**, extreme lethargy, rapid breathing, vomiting, or unusual weakness. - **Sun Protection**: Dapsone can cause **photosensitivity**. Protect your pet's exposed skin from prolonged sunlight. - **Cats**: If prescribed for a cat, understand that the risks of severe side effects are significantly higher.
Dapsone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。