Cortisone Acetate
別名: Cortisone
* **Strict Adherence**: It is critical to give this medication exactly as prescribed. **Do not stop the medication abruptly**, as this can trigger a life-threatening Addisonian crisis. * **Adverse Effects**: Watch for signs of stomach upset (vomiting, diarrhea, loss of appetite). If your pet is receiving higher doses, you may notice increased thirst, urination, and appetite, as well as panting. * **Veterinary Visits**: Keep all scheduled appointments for blood work (electrolytes) to ensure the dose is correct for your pet's needs. * **Stressful Events**: Contact your veterinarian if your pet is facing a stressful event (surgery, boarding, illness), as their dose may temporarily need to be increased.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Long-term treatment of hypoadrenocorticism (changeover period)
- Long-term treatment of hypoadrenocorticism (maintenance)
給藥方式
可能的副作用
- Vomiting
- Inappetence
- Diarrhea
- Hypersensitivity reactions (rare)
- Polyuria/Polydipsia/Polyphagia (at supra-physiologic doses)
- Panting (at supra-physiologic doses)
- Immunosuppression (at supra-physiologic doses)
注意事項與禁忌
- Hypersensitivity to cortisone acetate
- Systemic fungal infections (general corticosteroid contraindication)
- > **Laboratory Interference**: Cortisone cross-reacts with cortisol in the ACTH stimulation test. Baseline testing must be performed *before* administering cortisone (Note: Dexamethasone does not cross-react). * **Pregnancy**: FDA Category C. Excessive dosages early in pregnancy may lead to teratogenic effects. Glucocorticoids are necessary for normal fetal development, but high doses should be avoided. * **Nursing**: Unbound glucocorticoids enter milk. High doses or prolonged use may inhibit the growth of nursing newborns. * **Supra-physiologic Doses**: If used at higher than physiologic replacement doses, standard corticosteroid precautions apply (risk of iatrogenic Cushing's, immunosuppression, GI ulceration).
藥物相互作用
- Amphotericin B: Concomitant use may cause hypokalemia; risk of CHF and cardiac enlargement reported in humans.
- Aspirin: Glucocorticoids may reduce salicylate blood levels and increase risk for GI ulceration/bleeding.
- Diuretics, Potassium-Depleting (e.g., furosemide, thiazides): Concomitant administration may cause hypokalemia.
- Estrogens: May potentiate the effects of hydrocortisone/glucocorticoids.
- Insulin and Antidiabetic Agents: Insulin requirements may increase due to glucocorticoid-induced insulin resistance.
- Mitotane: May alter steroid metabolism; higher doses of steroids may be needed to treat mitotane-induced adrenal insufficiency.
- NSAIDs: Increased risk of gastrointestinal ulceration and bleeding.
- Vaccines (Live attenuated): Virus replication may be augmented if given at immunosuppressive doses; diminished immune response to killed vaccines/toxoids.
- Warfarin: May affect INR values; requires monitoring.
常見問題
Cortisone Acetate用於寵物有甚麼用途？
* **Strict Adherence**: It is critical to give this medication exactly as prescribed. **Do not stop the medication abruptly**, as this can trigger a life-threatening Addisonian crisis. * **Adverse Effects**: Watch for signs of stomach upset (vomiting, diarrhea, loss of appetite). If your pet is receiving higher doses, you may notice increased thirst, urination, and appetite, as well as panting. * **Veterinary Visits**: Keep all scheduled appointments for blood work (electrolytes) to ensure the dose is correct for your pet's needs. * **Stressful Events**: Contact your veterinarian if your pet is facing a stressful event (surgery, boarding, illness), as their dose may temporarily need to be increased.
Cortisone Acetate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。