Clofazimine
別名: Lamprene, Clofozine, Hansepran, Lamcoin, Lampren
**Administration:** * Unless otherwise instructed, give this medication **with food** to increase absorption and reduce stomach upset. **Important Warnings:** > **Discoloration:** This medication is a dye. It will likely cause your animal's skin to turn color (usually pink, but can range from red to orange to brown). It may also cause discoloring of tears, urine, feces, and other body fluids to a brownish-black color. * This discoloration is a normal, expected effect of the drug and is not harmful, but it can stain fabrics and may persist for many months after therapy is concluded. **Treatment Duration:** * Treatment for mycobacterial infections is very long (often months). Do not stop the medication early unless directed by your veterinarian, even if your pet seems better.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Avian mycobacteriosis
- Avian mycobacteriosis (recommended regime for raptors)
- Mycobacterium avium complex (MAC) as part of a multi-drug regimen
- M. avium intracellularae complex infections, leprosy, or opportunistic mycobacteriosis
- Mycobacterial infections
- Treatment of feline leprosy
- Treatment of localized atypical mycobacterial infections
- M. avium intracellularae complex infections, leprosy or opportunistic mycobacteriosis
- Mycobacterial infections (including feline leprosy)
給藥方式
可能的副作用
- Skin, eye, and body fluid discoloration (pink to brownish-black)
- Gastrointestinal pain, nausea, vomiting, diarrhea (dose-limiting)
- Hepatotoxicity (reported in a dog receiving concurrent rifampin)
- Photosensitization (reported in a cat)
- Nausea
- Diarrhoea
- Discoloration of skin, eyes, and body fluids (red-brown/orange)
- Renal impairment
- Hepatic impairment
- Photosensitization
注意事項與禁忌
- Use with caution in patients with pre-existing gastrointestinal conditions (diarrhea, abdominal pain)
- Known hypersensitivity to clofazimine
- Use with caution in patients with pre-existing gastrointestinal conditions such as diarrhea or abdominal pain. The drug is highly lipophilic and has an extremely long half-life, meaning adverse effects (like skin discoloration) can persist for months to years after discontinuation. It may be difficult to obtain and accurately dose for small animals.
藥物相互作用
- Isoniazid: May reduce clofazimine levels in the skin and increase amounts in plasma and urine; clinical significance is unclear.
- Dapsone: May reduce the anti-inflammatory effects of clofazimine; clinical significance is unclear.
常見問題
Clofazimine用於寵物有甚麼用途？
**Administration:** * Unless otherwise instructed, give this medication **with food** to increase absorption and reduce stomach upset. **Important Warnings:** > **Discoloration:** This medication is a dye. It will likely cause your animal's skin to turn color (usually pink, but can range from red to orange to brown). It may also cause discoloring of tears, urine, feces, and other body fluids to a brownish-black color. * This discoloration is a normal, expected effect of the drug and is not harmful, but it can stain fabrics and may persist for many months after therapy is concluded. **Treatment Duration:** * Treatment for mycobacterial infections is very long (often months). Do not stop the medication early unless directed by your veterinarian, even if your pet seems better.
Clofazimine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。