Chlorothiazide
別名: Diuril, Azide, Chlorzide, Chlotride, Diachlor, Diurigen, Pahtlisan, Saluric
* **Water Access:** Ensure your pet always has access to fresh drinking water unless specifically instructed otherwise by your veterinarian. * **Monitor for Dehydration/Imbalance:** Contact your veterinarian immediately if you notice signs of water or electrolyte imbalance, such as excessive thirst, severe lethargy, weakness, restlessness, reduced urination, vomiting, diarrhea, or a rapid heart rate. * **Administration:** Can be given with food if it causes stomach upset. * **Consistency:** Do not stop giving this medication abruptly without consulting your veterinarian, especially if it is being used to manage blood pressure or diabetes insipidus.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Treatment of diabetes insipidus
- As a diuretic
- General dosing for adult cattle
- General dosing
- Treatment of nephrogenic diabetes insipidus
- Treatment of systemic hypertension
- As a diuretic
給藥方式
可能的副作用
- Hypokalemia
- Hypochloremic alkalosis
- Dilutional hyponatremia
- Hypomagnesemia
- Hypercalcemia
- Hypophosphatemia
- Hyperuricemia
- Gastrointestinal distress (vomiting, diarrhea)
- Pancreatitis
- Hypersensitivity / dermatologic reactions
- Polyuria
- Hematologic toxicity
- Hyperglycemia
- Hyperlipidemias
注意事項與禁忌
- Hypersensitivity to thiazides or sulfonamides
- Anuria
- Pregnancy in otherwise healthy females with only mild edema (relative contraindication)
- Use with **extreme caution** or avoid in patients with severe renal disease, preexisting electrolyte or water balance abnormalities, impaired hepatic function (may precipitate hepatic coma), hyperuricemia, systemic lupus erythematosus (SLE), or diabetes mellitus. Monitor patients with conditions that may lead to fluid/electrolyte loss (e.g., vomiting, diarrhea) very carefully.
藥物相互作用
- Amphotericin B: Increased risk for severe hypokalemia
- Corticosteroids / Corticotropin: Increased risk for severe hypokalemia
- Diazoxide: Increased risk for hyperglycemia, hyperuricemia, and hypotension
- Digitalis / Digoxin: Thiazide-induced hypokalemia, hypomagnesemia, and/or hypercalcemia may increase the likelihood of digitalis toxicity
- Insulin: Thiazides may increase insulin requirements
- Lithium: Thiazides can increase serum lithium concentrations
- Methenamine: Thiazides can alkalinize urine and reduce methenamine effectiveness
- NSAIDs: May increase risk for renal toxicity; NSAIDs may reduce diuretic actions of thiazides
- Neuromuscular blocking agents: Response or duration of nondepolarizing agents (e.g., tubocurarine) may be increased
- Probenecid: Blocks thiazide-induced uric acid retention
- Quinidine: Half-life may be prolonged by thiazides due to urine alkalinization
常見問題
Chlorothiazide用於寵物有甚麼用途？
* **Water Access:** Ensure your pet always has access to fresh drinking water unless specifically instructed otherwise by your veterinarian. * **Monitor for Dehydration/Imbalance:** Contact your veterinarian immediately if you notice signs of water or electrolyte imbalance, such as excessive thirst, severe lethargy, weakness, restlessness, reduced urination, vomiting, diarrhea, or a rapid heart rate. * **Administration:** Can be given with food if it causes stomach upset. * **Consistency:** Do not stop giving this medication abruptly without consulting your veterinarian, especially if it is being used to manage blood pressure or diabetes insipidus.
Chlorothiazide對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。