Busulfan
別名: Myleran, Busulfex, Busulivex, Mielucin, Misulban
> **Important Safety Warning**: Busulfan is a potent chemotherapy drug. Handle with extreme care to protect yourself, your family, and the environment. * **Handling**: Always wear disposable gloves when handling the medication. Wash hands thoroughly afterward. Do not crush, break, or split tablets. * **Waste Management**: Treat your pet's waste (urine, feces, vomit) as hazardous for at least 48-72 hours post-dose. Clean up with gloves and dispose of waste in sealed plastic bags. * **Adverse Signs**: Contact your veterinarian *immediately* if you notice signs of toxicity such as: * Abnormal bleeding or unexplained bruising (signs of low platelets) * Lethargy, severe depression, or weakness (signs of anemia) * Fever or signs of infection (signs of low white blood cells) * Shortness of breath or difficulty breathing * Changes in urination
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive therapy of chronic granulocytic leukemias or polycythemia vera
- Adjunctive therapy of chronic granulocytic leukemias or polycythemia vera
給藥方式
可能的副作用
- Myelosuppression (anemia, leukopenia, thrombocytopenia)
- Pancytopenia (can take months to years for recovery)
- Bronchopulmonary dysplasia with pulmonary fibrosis (uncommon, chronic use)
- Uric acid nephropathy
- Stomatitis
注意事項與禁忌
- Patients with known hypersensitivity to busulfan
- Patients who have shown resistance to the drug in the past
- Pregnancy (FDA Category D), unless potential benefits outweigh the risks
- Nursing dams
- > **Warning**: Only veterinarians with the experience and resources to monitor the toxicity of this agent should administer this drug. * **Bone Marrow Depression**: The risk versus benefits of therapy must be carefully considered in patients with preexisting bone marrow depression or concurrent infections. * **Radiation Therapy**: Additive bone marrow depression may occur in patients undergoing concomitant radiation therapy. * **Teratogenicity**: Mutagenic in mice and may potentially cause a variety of fetal abnormalities. Avoid during pregnancy unless absolutely necessary.
藥物相互作用
- Acetaminophen: Use within 72 hours prior to busulfan can reduce busulfan clearance by reducing glutathione concentrations in tissues and blood.
- Cyclophosphamide: Can potentially reduce clearance of busulfan, probably by competing for available glutathione.
- Itraconazole: Potential decreased busulfan clearance.
- Myelosuppressant agents: Concurrent use with other bone marrow depressant medications may result in additive myelosuppression.
- Phenytoin: Possible increased clearance of busulfan.
- Thioguanine: Used concomitantly with busulfan may result in hepatotoxicity.
常見問題
Busulfan用於寵物有甚麼用途？
> **Important Safety Warning**: Busulfan is a potent chemotherapy drug. Handle with extreme care to protect yourself, your family, and the environment. * **Handling**: Always wear disposable gloves when handling the medication. Wash hands thoroughly afterward. Do not crush, break, or split tablets. * **Waste Management**: Treat your pet's waste (urine, feces, vomit) as hazardous for at least 48-72 hours post-dose. Clean up with gloves and dispose of waste in sealed plastic bags. * **Adverse Signs**: Contact your veterinarian *immediately* if you notice signs of toxicity such as: * Abnormal bleeding or unexplained bruising (signs of low platelets) * Lethargy, severe depression, or weakness (signs of anemia) * Fever or signs of infection (signs of low white blood cells) * Shortness of breath or difficulty breathing * Changes in urination
Busulfan對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。